21NW

Cryo-EM structure of human Lipid Phosphate Phosphatase 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005769	cellular_component	early endosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0005901	cellular_component	caveola
A	0006644	biological_process	phospholipid metabolic process
A	0006670	biological_process	sphingosine metabolic process
A	0006672	biological_process	ceramide metabolic process
A	0007165	biological_process	signal transduction
A	0008195	molecular_function	phosphatidate phosphatase activity
A	0016020	cellular_component	membrane
A	0030149	biological_process	sphingolipid catabolic process
A	0031901	cellular_component	early endosome membrane
A	0042392	molecular_function	sphingosine-1-phosphate phosphatase activity
A	0046839	biological_process	phospholipid dephosphorylation
A	0106235	molecular_function	ceramide-1-phosphate phosphatase activity
B	0005515	molecular_function	protein binding
B	0005769	cellular_component	early endosome
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0005901	cellular_component	caveola
B	0006644	biological_process	phospholipid metabolic process
B	0006670	biological_process	sphingosine metabolic process
B	0006672	biological_process	ceramide metabolic process
B	0007165	biological_process	signal transduction
B	0008195	molecular_function	phosphatidate phosphatase activity
B	0016020	cellular_component	membrane
B	0030149	biological_process	sphingolipid catabolic process
B	0031901	cellular_component	early endosome membrane
B	0042392	molecular_function	sphingosine-1-phosphate phosphatase activity
B	0046839	biological_process	phospholipid dephosphorylation
B	0106235	molecular_function	ceramide-1-phosphate phosphatase activity
C	0005515	molecular_function	protein binding
C	0005769	cellular_component	early endosome
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0005901	cellular_component	caveola
C	0006644	biological_process	phospholipid metabolic process
C	0006670	biological_process	sphingosine metabolic process
C	0006672	biological_process	ceramide metabolic process
C	0007165	biological_process	signal transduction
C	0008195	molecular_function	phosphatidate phosphatase activity
C	0016020	cellular_component	membrane
C	0030149	biological_process	sphingolipid catabolic process
C	0031901	cellular_component	early endosome membrane
C	0042392	molecular_function	sphingosine-1-phosphate phosphatase activity
C	0046839	biological_process	phospholipid dephosphorylation
C	0106235	molecular_function	ceramide-1-phosphate phosphatase activity
D	0005515	molecular_function	protein binding
D	0005769	cellular_component	early endosome
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005886	cellular_component	plasma membrane
D	0005901	cellular_component	caveola
D	0006644	biological_process	phospholipid metabolic process
D	0006670	biological_process	sphingosine metabolic process
D	0006672	biological_process	ceramide metabolic process
D	0007165	biological_process	signal transduction
D	0008195	molecular_function	phosphatidate phosphatase activity
D	0016020	cellular_component	membrane
D	0030149	biological_process	sphingolipid catabolic process
D	0031901	cellular_component	early endosome membrane
D	0042392	molecular_function	sphingosine-1-phosphate phosphatase activity
D	0046839	biological_process	phospholipid dephosphorylation
D	0106235	molecular_function	ceramide-1-phosphate phosphatase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	480
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	344
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Region: {"description":"Phosphatase sequence motif I","evidences":[{"source":"UniProtKB","id":"O34349","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Region: {"description":"Phosphatase sequence motif II","evidences":[{"source":"UniProtKB","id":"O34349","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	44
Details	Region: {"description":"Phosphatase sequence motif III","evidences":[{"source":"UniProtKB","id":"O34349","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Active site: {"description":"Proton donors","evidences":[{"source":"UniProtKB","id":"O34349","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"O34349","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Stabilizes the active site histidine for nucleophilic attack","evidences":[{"source":"UniProtKB","id":"O34349","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---