1ZZW
Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
| B | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | ASP377 |
| A | CYS408 |
| A | GLN409 |
| A | ALA410 |
| A | GLY411 |
| A | VAL412 |
| A | SER413 |
| A | ARG414 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 502 |
| Chain | Residue |
| B | CYS408 |
| B | GLN409 |
| B | ALA410 |
| B | GLY411 |
| B | VAL412 |
| B | SER413 |
| B | ARG414 |
| B | HOH226 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 503 |
| Chain | Residue |
| B | HOH255 |
| B | SER413 |
| B | THR417 |
| B | ILE445 |
| B | SER446 |
| B | ASN448 |
| B | PHE451 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCqaGvsRSA |
| Chain | Residue | Details |
| A | ILE406-ALA416 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 286 |
| Details | Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16806267","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17400920","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
