Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004517 | molecular_function | nitric-oxide synthase activity |
| A | 0006809 | biological_process | nitric oxide biosynthetic process |
| A | 0020037 | molecular_function | heme binding |
| B | 0004517 | molecular_function | nitric-oxide synthase activity |
| B | 0006809 | biological_process | nitric oxide biosynthetic process |
| B | 0020037 | molecular_function | heme binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 860 |
| Chain | Residue |
| A | GLY417 |
| A | TRP587 |
| A | ALA654 |
| A | SER657 |
| A | HOH1108 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 861 |
| Chain | Residue |
| B | HOH1078 |
| B | HOH1117 |
| B | TRP587 |
| B | VAL649 |
| B | SER657 |
| B | HOH1070 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 900 |
| Chain | Residue |
| A | CYS326 |
| A | CYS331 |
| B | CYS326 |
| B | CYS331 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MTL A 870 |
| Chain | Residue |
| A | SER477 |
| A | ARG481 |
| A | ALA497 |
| A | ASN498 |
| A | GLN500 |
| A | PHE501 |
| A | ASN569 |
| A | ASP709 |
| A | TRP711 |
| A | DP9799 |
| A | HOH1067 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MTL B 871 |
| Chain | Residue |
| B | SER477 |
| B | ALA497 |
| B | ASN498 |
| B | GLN500 |
| B | PHE501 |
| B | ASN569 |
| B | ASP709 |
| B | TRP711 |
| B | DP9800 |
| B | HOH1056 |
| B | HOH1130 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE HEM A 750 |
| Chain | Residue |
| A | TRP409 |
| A | CYS415 |
| A | SER457 |
| A | PHE584 |
| A | SER585 |
| A | GLY586 |
| A | TRP587 |
| A | GLU592 |
| A | TRP678 |
| A | TYR706 |
| A | H4B760 |
| A | DP9799 |
| A | HOH904 |
| A | HOH905 |
| A | HOH922 |
| A | HOH981 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE H4B A 760 |
| Chain | Residue |
| A | SER334 |
| A | MET336 |
| A | ARG596 |
| A | VAL677 |
| A | TRP678 |
| A | HEM750 |
| A | HOH902 |
| A | HOH904 |
| A | HOH908 |
| A | HOH1033 |
| A | HOH1079 |
| B | TRP676 |
| B | PHE691 |
| B | HIS692 |
| B | GLN693 |
| B | GLU694 |
| site_id | AC8 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE DP9 A 799 |
| Chain | Residue |
| A | GLN478 |
| A | ARG481 |
| A | PRO565 |
| A | VAL567 |
| A | ASN569 |
| A | MET570 |
| A | SER585 |
| A | GLY586 |
| A | TRP587 |
| A | GLU592 |
| A | TYR706 |
| A | HEM750 |
| A | MTL870 |
| A | HOH904 |
| A | HOH912 |
| A | HOH922 |
| A | HOH936 |
| A | HOH939 |
| A | HOH945 |
| A | HOH947 |
| A | HOH955 |
| A | HOH1022 |
| A | HOH1083 |
| A | HOH1110 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE HEM B 750 |
| Chain | Residue |
| B | GLU592 |
| B | TRP678 |
| B | TYR706 |
| B | H4B761 |
| B | DP9800 |
| B | HOH888 |
| B | HOH890 |
| B | HOH897 |
| B | HOH956 |
| B | HOH1093 |
| B | TRP409 |
| B | CYS415 |
| B | SER457 |
| B | PHE584 |
| B | SER585 |
| B | TRP587 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE H4B B 761 |
| Chain | Residue |
| A | TRP676 |
| A | PHE691 |
| A | HIS692 |
| A | GLN693 |
| A | GLU694 |
| B | SER334 |
| B | ARG596 |
| B | VAL677 |
| B | TRP678 |
| B | HEM750 |
| B | HOH878 |
| B | HOH890 |
| B | HOH945 |
| B | HOH1100 |
| B | HOH1102 |
| site_id | BC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE DP9 B 800 |
| Chain | Residue |
| B | GLN478 |
| B | ARG481 |
| B | PRO565 |
| B | VAL567 |
| B | ASN569 |
| B | MET570 |
| B | SER585 |
| B | GLY586 |
| B | TRP587 |
| B | GLU592 |
| B | TYR706 |
| B | HEM750 |
| B | MTL871 |
| B | HOH890 |
| B | HOH897 |
| B | HOH908 |
| B | HOH911 |
| B | HOH926 |
| B | HOH944 |
| B | HOH951 |
| B | HOH956 |
| B | HOH968 |
| B | HOH1095 |
| B | HOH1096 |
Functional Information from PROSITE/UniProt
| site_id | PS60001 |
| Number of Residues | 8 |
| Details | NOS Nitric oxide synthase (NOS) signature. RCVGRIqW |
| Chain | Residue | Details |
| A | ARG414-TRP421 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P29475","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P29475","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| A | CYS415 | |
| A | TRP587 | |
| A | GLU592 | |
| A | ARG418 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| B | CYS415 | |
| B | TRP587 | |
| B | GLU592 | |
| B | ARG418 | |
