1ZZC

Crystal Structure of CoII HppE in Complex with Tris Buffer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008198	molecular_function	ferrous iron binding
A	0016491	molecular_function	oxidoreductase activity
A	0016717	molecular_function	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
A	0017000	biological_process	antibiotic biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0051289	biological_process	protein homotetramerization
A	0055114	biological_process	obsolete oxidation-reduction process
A	1901766	biological_process	phosphinothricin biosynthetic process
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005829	cellular_component	cytosol
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008198	molecular_function	ferrous iron binding
B	0016491	molecular_function	oxidoreductase activity
B	0016717	molecular_function	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
B	0017000	biological_process	antibiotic biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
B	0051289	biological_process	protein homotetramerization
B	0055114	biological_process	obsolete oxidation-reduction process
B	1901766	biological_process	phosphinothricin biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CO A 199

Chain	Residue
A	HIS138
A	GLU142
A	HIS180
A	TRS503

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CO B 199

Chain	Residue
B	HIS138
B	GLU142
B	HIS180
B	TRS504

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TRS A 503

Chain	Residue
A	ASN135
A	HIS138
A	GLU142
A	HIS180
A	PHE182
A	ASN197
A	CO199
A	HOH605
B	LYS23
A	LEU120

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TRS B 504

Chain	Residue
A	LYS23
B	TYR105
B	LEU120
B	ASN135
B	HIS138
B	GLU142
B	HIS180
B	PHE182
B	ASN197
B	CO199
B	HOH643

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	110
Details	Domain: {"description":"HTH cro/C1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00257","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	38
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00257","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16186494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21682308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16015285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16186494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21682308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16015285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16186494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21682308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16015285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16186494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21682308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16015285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16186494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21682308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	60
Details	Domain: {"description":"Cupin type-2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---