1ZZ1

Crystal structure of a HDAC-like protein with SAHA bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004407	molecular_function	histone deacetylase activity
A	0016787	molecular_function	hydrolase activity
A	0040029	biological_process	epigenetic regulation of gene expression
A	0046872	molecular_function	metal ion binding
B	0004407	molecular_function	histone deacetylase activity
B	0016787	molecular_function	hydrolase activity
B	0040029	biological_process	epigenetic regulation of gene expression
B	0046872	molecular_function	metal ion binding
C	0004407	molecular_function	histone deacetylase activity
C	0016787	molecular_function	hydrolase activity
C	0040029	biological_process	epigenetic regulation of gene expression
C	0046872	molecular_function	metal ion binding
D	0004407	molecular_function	histone deacetylase activity
D	0016787	molecular_function	hydrolase activity
D	0040029	biological_process	epigenetic regulation of gene expression
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2451

Chain	Residue
A	ASP180
A	HIS182
A	ASP268
A	SHH2452

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2551

Chain	Residue
B	ASP180
B	HIS182
B	ASP268
B	SHH2552

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 2651

Chain	Residue
C	HIS182
C	ASP268
C	SHH2652
C	ASP180

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 2751

Chain	Residue
D	ASP180
D	HIS182
D	ASP268
D	SHH2752

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 2450

Chain	Residue
A	ASP178
A	ASP180
A	HIS182
A	SER201
A	LEU202

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K B 2550

Chain	Residue
B	ASP178
B	ASP180
B	HIS182
B	SER201
B	LEU202

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K C 2650

Chain	Residue
C	ASP178
C	ASP180
C	HIS182
C	SER201
C	LEU202

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K D 2750

Chain	Residue
D	ASP178
D	ASP180
D	HIS182
D	SER201
D	LEU202

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 2449

Chain	Residue
A	TRP191
A	ASP194
A	VAL197
A	TYR226
A	HOH2501

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K B 2549

Chain	Residue
B	TRP191
B	ASP194
B	VAL197
B	TYR226
B	HOH2604

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 2649

Chain	Residue
C	TRP191
C	ASP194
C	VAL197
C	TYR226
C	HOH2767
C	HOH2774

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K D 2749

Chain	Residue
D	TRP191
D	ASP194
D	VAL197
D	TYR226
D	HOH2822

---

site_id	BC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SHH A 2452

Chain	Residue
A	ASP98
A	ILE100
A	HIS142
A	HIS143
A	PHE152
A	ASP180
A	HIS182
A	PHE208
A	ASP268
A	TYR312
A	ZN2451
A	HOH2583

---

site_id	BC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SHH B 2552

Chain	Residue
B	LEU21
B	ASP98
B	ILE100
B	HIS142
B	HIS143
B	PHE152
B	ASP180
B	HIS182
B	PHE208
B	ASP268
B	TYR312
B	ZN2551
B	HOH2739
C	PHE341

---

site_id	BC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SHH C 2652

Chain	Residue
C	ASP98
C	ILE100
C	HIS142
C	HIS143
C	PHE152
C	ASP180
C	HIS182
C	PHE208
C	ASP268
C	TYR312
C	ZN2651

---

site_id	BC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SHH D 2752

Chain	Residue
D	HIS182
D	PHE208
D	ASP268
D	TYR312
D	ZN2751
D	HOH2897
D	ILE100
D	HIS142
D	HIS143
D	PHE152
D	ASP180

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27756124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G1C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Polarizes the scissile carbonyl of the substrate","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---