1ZZ0

Crystal structure of a HDAC-like protein with acetate bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1451

Chain	Residue
A	ASP180
A	HIS182
A	ASP268
A	ACT1452

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1551

Chain	Residue
B	ASP180
B	HIS182
B	ASP268
B	ACT1552

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1651

Chain	Residue
C	HIS182
C	ASP268
C	ACT1652
C	ASP180

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1751

Chain	Residue
D	ASP180
D	HIS182
D	ASP268
D	ACT1752

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 1449

Chain	Residue
A	ASP178
A	ASP180
A	HIS182
A	SER201
A	LEU202

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K A 1450

Chain	Residue
A	TRP191
A	ASP194
A	VAL197
A	THR199
A	TYR226
A	HOH1463
A	HOH1476

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K B 1549

Chain	Residue
B	ASP178
B	ASP180
B	HIS182
B	SER201
B	LEU202

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K B 1550

Chain	Residue
B	TRP191
B	ASP194
B	VAL197
B	TYR226
B	HOH1555
B	HOH1584

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K C 1649

Chain	Residue
C	ASP178
C	ASP180
C	HIS182
C	SER201
C	LEU202

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 1650

Chain	Residue
C	TRP191
C	ASP194
C	VAL197
C	TYR226
C	HOH1658
C	HOH1671

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K D 1749

Chain	Residue
D	TRP191
D	ASP194
D	VAL197
D	THR199
D	TYR226
D	HOH1784
D	HOH1785

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K D 1750

Chain	Residue
D	ASP178
D	ASP180
D	HIS182
D	SER201
D	LEU202

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT A 1452

Chain	Residue
A	HIS142
A	HIS143
A	GLY151
A	ASP180
A	HIS182
A	ASP268
A	GLY310
A	TYR312
A	ZN1451

---

site_id	BC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT B 1552

Chain	Residue
B	HIS142
B	HIS143
B	GLY151
B	ASP180
B	HIS182
B	ASP268
B	GLY310
B	TYR312
B	ZN1551

---

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT C 1652

Chain	Residue
C	HIS142
C	HIS143
C	GLY151
C	ASP180
C	HIS182
C	ASP268
C	GLY310
C	TYR312
C	ZN1651

---

site_id	BC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT D 1752

Chain	Residue
D	HIS142
D	HIS143
D	GLY151
D	ASP180
D	HIS182
D	ASP268
D	GLY310
D	TYR312
D	ZN1751

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:Q48935

Chain	Residue	Details
A	ALA144
B	ALA144
C	ALA144
D	ALA144

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:27756124, ECO:0007744|PDB:5G1C

Chain	Residue	Details
A	VAL181
D	VAL181
D	HIS183
D	ALA269
A	HIS183
A	ALA269
B	VAL181
B	HIS183
B	ALA269
C	VAL181
C	HIS183
C	ALA269

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Polarizes the scissile carbonyl of the substrate => ECO:0000250|UniProtKB:Q48935

Chain	Residue	Details
A	SER313
B	SER313
C	SER313
D	SER313

---