Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004407 | molecular_function | histone deacetylase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0040029 | biological_process | epigenetic regulation of gene expression |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004407 | molecular_function | histone deacetylase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0040029 | biological_process | epigenetic regulation of gene expression |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004407 | molecular_function | histone deacetylase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0040029 | biological_process | epigenetic regulation of gene expression |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004407 | molecular_function | histone deacetylase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0040029 | biological_process | epigenetic regulation of gene expression |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1451 |
| Chain | Residue |
| A | ASP180 |
| A | HIS182 |
| A | ASP268 |
| A | ACT1452 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1551 |
| Chain | Residue |
| B | ASP180 |
| B | HIS182 |
| B | ASP268 |
| B | ACT1552 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1651 |
| Chain | Residue |
| C | HIS182 |
| C | ASP268 |
| C | ACT1652 |
| C | ASP180 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1751 |
| Chain | Residue |
| D | ASP180 |
| D | HIS182 |
| D | ASP268 |
| D | ACT1752 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 1449 |
| Chain | Residue |
| A | ASP178 |
| A | ASP180 |
| A | HIS182 |
| A | SER201 |
| A | LEU202 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K A 1450 |
| Chain | Residue |
| A | TRP191 |
| A | ASP194 |
| A | VAL197 |
| A | THR199 |
| A | TYR226 |
| A | HOH1463 |
| A | HOH1476 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 1549 |
| Chain | Residue |
| B | ASP178 |
| B | ASP180 |
| B | HIS182 |
| B | SER201 |
| B | LEU202 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K B 1550 |
| Chain | Residue |
| B | TRP191 |
| B | ASP194 |
| B | VAL197 |
| B | TYR226 |
| B | HOH1555 |
| B | HOH1584 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K C 1649 |
| Chain | Residue |
| C | ASP178 |
| C | ASP180 |
| C | HIS182 |
| C | SER201 |
| C | LEU202 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 1650 |
| Chain | Residue |
| C | TRP191 |
| C | ASP194 |
| C | VAL197 |
| C | TYR226 |
| C | HOH1658 |
| C | HOH1671 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K D 1749 |
| Chain | Residue |
| D | TRP191 |
| D | ASP194 |
| D | VAL197 |
| D | THR199 |
| D | TYR226 |
| D | HOH1784 |
| D | HOH1785 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K D 1750 |
| Chain | Residue |
| D | ASP178 |
| D | ASP180 |
| D | HIS182 |
| D | SER201 |
| D | LEU202 |
| site_id | BC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACT A 1452 |
| Chain | Residue |
| A | HIS142 |
| A | HIS143 |
| A | GLY151 |
| A | ASP180 |
| A | HIS182 |
| A | ASP268 |
| A | GLY310 |
| A | TYR312 |
| A | ZN1451 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACT B 1552 |
| Chain | Residue |
| B | HIS142 |
| B | HIS143 |
| B | GLY151 |
| B | ASP180 |
| B | HIS182 |
| B | ASP268 |
| B | GLY310 |
| B | TYR312 |
| B | ZN1551 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACT C 1652 |
| Chain | Residue |
| C | HIS142 |
| C | HIS143 |
| C | GLY151 |
| C | ASP180 |
| C | HIS182 |
| C | ASP268 |
| C | GLY310 |
| C | TYR312 |
| C | ZN1651 |
| site_id | BC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACT D 1752 |
| Chain | Residue |
| D | HIS142 |
| D | HIS143 |
| D | GLY151 |
| D | ASP180 |
| D | HIS182 |
| D | ASP268 |
| D | GLY310 |
| D | TYR312 |
| D | ZN1751 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27756124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G1C","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Polarizes the scissile carbonyl of the substrate","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
