1ZX9
Crystal Structure of Tn501 MerA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016152 | molecular_function | mercury (II) reductase (NADP+) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0045340 | molecular_function | mercury ion binding |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| A | 0050787 | biological_process | detoxification of mercury ion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 39 |
| Details | BINDING SITE FOR RESIDUE FAD A 666 |
| Chain | Residue |
| A | ILE10 |
| A | THR41 |
| A | CYS42 |
| A | GLY46 |
| A | CYS47 |
| A | SER50 |
| A | LYS51 |
| A | GLY115 |
| A | GLU116 |
| A | ALA117 |
| A | ALA145 |
| A | GLY11 |
| A | THR146 |
| A | GLY147 |
| A | ARG269 |
| A | SER275 |
| A | LEU276 |
| A | GLY308 |
| A | ASP309 |
| A | GLN315 |
| A | PHE316 |
| A | VAL317 |
| A | GLY13 |
| A | TYR318 |
| A | PHE348 |
| A | HOH1001 |
| A | HOH1005 |
| A | HOH1006 |
| A | HOH1032 |
| A | HOH1048 |
| A | HOH1072 |
| A | HOH1133 |
| A | HOH1173 |
| A | GLY14 |
| A | ALA15 |
| A | ILE33 |
| A | GLU34 |
| A | ARG35 |
| A | GLY40 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP |
| Chain | Residue | Details |
| A | GLY39-PRO49 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16114877, ECO:0007744|PDB:1ZK7 |
| Chain | Residue | Details |
| A | ALA16 | |
| A | GLY36 | |
| A | THR41 | |
| A | LYS51 | |
| A | ALA117 | |
| A | ASP309 | |
| A | VAL317 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|Ref.5, ECO:0007744|PDB:4K7Z |
| Chain | Residue | Details |
| A | CYS464 | |
| A | CYS465 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | TYR441 | |
| A | GLU446 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | CYS42 | |
| A | CYS47 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 277 |
| Chain | Residue | Details |
| A | CYS42 | activator, covalently attached, hydrogen bond acceptor, metal ligand, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | CYS47 | activator, electrofuge, electrophile, metal ligand, nucleofuge, nucleophile, polar interaction |
| A | CYS464 | activator, electrostatic stabiliser, metal ligand, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | CYS465 | activator, covalently attached, electrostatic stabiliser, hydrogen bond acceptor, metal ligand, nucleofuge, nucleophile, proton acceptor, proton donor |
