Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1ZT2

Heterodimeric structure of the core primase.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003896	molecular_function	DNA primase activity
A	0005515	molecular_function	protein binding
A	0006259	biological_process	DNA metabolic process
A	0006260	biological_process	DNA replication
A	0006269	biological_process	DNA replication, synthesis of primer
A	0016779	molecular_function	nucleotidyltransferase activity
A	0046872	molecular_function	metal ion binding
A	1990077	cellular_component	primosome complex
B	0003896	molecular_function	DNA primase activity
B	0006269	biological_process	DNA replication, synthesis of primer
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003896	molecular_function	DNA primase activity
C	0005515	molecular_function	protein binding
C	0006259	biological_process	DNA metabolic process
C	0006260	biological_process	DNA replication
C	0006269	biological_process	DNA replication, synthesis of primer
C	0016779	molecular_function	nucleotidyltransferase activity
C	0046872	molecular_function	metal ion binding
C	1990077	cellular_component	primosome complex
D	0003896	molecular_function	DNA primase activity
D	0006269	biological_process	DNA replication, synthesis of primer

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 999

Chain	Residue
A	CYS116
A	CYS119
A	CYS128
A	ASP131

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 999

Chain	Residue
C	CYS116
C	CYS119
C	CYS128
C	ASP131

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1000

Chain	Residue
A	ASN175
A	ARG176
A	HIS253
A	SO41009
A	SER173

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1001

Chain	Residue
A	LYS255
A	ASN321
A	SO41012

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 213

Chain	Residue
B	HIS164
B	LYS165

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 1002

Chain	Residue
A	ARG303

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1000

Chain	Residue
A	LYS15
A	ARG19
C	SER55

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 214

Chain	Residue
B	ARG95
B	HIS99

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1001

Chain	Residue
C	SER173
C	ASN175
C	ARG176
C	HIS253
C	SO41004

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1002

Chain	Residue
A	ASN132
C	LYS169
C	ARG262

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 1003

Chain	Residue
C	ARG303

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 213

Chain	Residue
D	ARG95
D	TRP156

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 215

Chain	Residue
B	SO4218
C	ASN302

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1003

Chain	Residue
A	LYS109
A	SER215
A	ASN217

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1004

Chain	Residue
A	THR47
A	TYR48

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1005

Chain	Residue
A	ASP235
A	GLN237
A	ARG244

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1006

Chain	Residue
A	THR289
A	ARG303

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1004

Chain	Residue
C	HIS179
C	ARG247
C	HIS253
C	SO41001

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 1005

Chain	Residue
C	ASN321

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 214

Chain	Residue
D	GLU103
D	LYS172

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1006

Chain	Residue
A	SO41007
C	SER56
C	SER57
C	GLU58

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1007

Chain	Residue
A	GLY9
A	GLN10
C	SO41006

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 1007

Chain	Residue
C	SER215

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1008

Chain	Residue
C	ASN175
C	ARG176
C	LYS255
C	ARG320

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 216

Chain	Residue
B	LYS130
B	ARG132

site_id	CC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 1008

Chain	Residue
A	LYS169

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1009

Chain	Residue
A	ASP101
A	HIS179
A	ARG247
A	SO41000

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 217

Chain	Residue
B	ARG132
B	ILE133
B	ILE134
B	GLN135

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1010

Chain	Residue
A	SER56
A	SER57

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 218

Chain	Residue
B	PRO200
B	GLU201
B	SO4215
C	LYS300

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1010

Chain	Residue
C	SER45
C	ASP46
C	THR47

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 219

Chain	Residue
B	ASN102
B	GLU103
B	LYS172

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1011

Chain	Residue
A	ALA122
A	VAL123
A	VAL124
A	SER125

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 1011

Chain	Residue
C	SER125
C	GLU126

site_id	DC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1012

Chain	Residue
A	LYS255
A	SO41001

site_id	DC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1012

Chain	Residue
C	ARG148
C	CYS108
C	LYS109

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 215

Chain	Residue
D	ILE199
D	PRO200
D	GLU201

site_id	EC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 1013

Chain	Residue
C	LYS15
C	ARG19

site_id	EC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 220

Chain	Residue
B	LYS81
B	ARG84
B	ARG85

site_id	EC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1014

Chain	Residue
C	CYS184
C	TYR185
C	GLY186

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00700

Chain	Residue	Details
A	ASP101
A	ASP103
A	ASP235
C	ASP101
C	ASP103
C	ASP235

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:16273105

Chain	Residue	Details
A	CYS116
A	CYS119
A	CYS128
A	ASP131
C	CYS116
C	CYS119
C	CYS128
C	ASP131

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)