1ZRF
4 crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-[6C;17G]ICAP38 DNA
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0003680 | molecular_function | minor groove of adenine-thymine-rich DNA binding |
A | 0003700 | molecular_function | DNA-binding transcription factor activity |
A | 0005515 | molecular_function | protein binding |
A | 0005829 | cellular_component | cytosol |
A | 0006351 | biological_process | DNA-templated transcription |
A | 0006355 | biological_process | regulation of DNA-templated transcription |
A | 0008301 | molecular_function | DNA binding, bending |
A | 0030552 | molecular_function | cAMP binding |
A | 0032993 | cellular_component | protein-DNA complex |
A | 0042802 | molecular_function | identical protein binding |
A | 0043565 | molecular_function | sequence-specific DNA binding |
A | 0045013 | biological_process | carbon catabolite repression of transcription |
A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
B | 0003677 | molecular_function | DNA binding |
B | 0003680 | molecular_function | minor groove of adenine-thymine-rich DNA binding |
B | 0003700 | molecular_function | DNA-binding transcription factor activity |
B | 0005515 | molecular_function | protein binding |
B | 0005829 | cellular_component | cytosol |
B | 0006351 | biological_process | DNA-templated transcription |
B | 0006355 | biological_process | regulation of DNA-templated transcription |
B | 0008301 | molecular_function | DNA binding, bending |
B | 0030552 | molecular_function | cAMP binding |
B | 0032993 | cellular_component | protein-DNA complex |
B | 0042802 | molecular_function | identical protein binding |
B | 0043565 | molecular_function | sequence-specific DNA binding |
B | 0045013 | biological_process | carbon catabolite repression of transcription |
B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE CMP A 622 |
Chain | Residue |
A | VAL49 |
A | HOH2626 |
A | HOH2656 |
B | LEU124 |
B | SER128 |
A | GLY71 |
A | GLU72 |
A | LEU73 |
A | ARG82 |
A | SER83 |
A | ALA84 |
A | THR127 |
A | HOH2625 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE CMP B 1622 |
Chain | Residue |
A | SER128 |
B | VAL49 |
B | ILE70 |
B | GLY71 |
B | GLU72 |
B | LEU73 |
B | ARG82 |
B | SER83 |
B | ALA84 |
B | THR127 |
B | HOH3628 |
B | HOH3639 |
site_id | AC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE CMP A 2622 |
Chain | Residue |
A | LYS57 |
A | GLU58 |
A | GLN170 |
A | GLY173 |
A | GLN174 |
A | GLY177 |
A | CYS178 |
A | ARG180 |
A | HOH2639 |
B | ALA135 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE CMP B 3622 |
Chain | Residue |
A | ALA135 |
B | LYS57 |
B | GLU58 |
B | GLN170 |
B | GLY173 |
B | GLN174 |
B | GLY177 |
B | CYS178 |
B | SER179 |
B | ARG180 |
B | HOH3690 |
Z | DA9 |
site_id | AC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DIO B 301 |
Chain | Residue |
B | ALA144 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DIO B 302 |
Chain | Residue |
B | LYS130 |
B | ARG142 |
B | THR146 |
B | ILE175 |
B | VAL176 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DIO A 303 |
Chain | Residue |
A | LEU148 |
A | LEU195 |
A | VAL205 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DIO A 304 |
Chain | Residue |
A | LEU11 |
A | PHE14 |
A | TYR41 |
A | PHE69 |
A | ILE112 |
A | ARG115 |
A | ARG209 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DIO A 305 |
Chain | Residue |
A | LYS130 |
A | ARG142 |
A | THR146 |
A | ILE175 |
A | VAL176 |
A | HOH2661 |
Functional Information from PROSITE/UniProt
site_id | PS00042 |
Number of Residues | 24 |
Details | HTH_CRP_1 Crp-type HTH domain signature. ITRqeIGqIVGcSreTv.GRiLkmL |
Chain | Residue | Details |
A | ILE167-LEU190 |
site_id | PS00888 |
Number of Residues | 17 |
Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. LIhQGEkAEtLYYIvkG |
Chain | Residue | Details |
A | LEU29-GLY45 |
site_id | PS00889 |
Number of Residues | 19 |
Details | CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. IGElGLfeegqe.....RSAwVrA |
Chain | Residue | Details |
A | ILE70-ALA88 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00387 |
Chain | Residue | Details |
A | SER179-ARG185 | |
B | SER179-ARG185 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802 |
Chain | Residue | Details |
A | GLY56 | |
B | THR127 | |
B | ALA135 | |
B | GLN170 | |
A | GLY71 | |
A | ARG82 | |
A | THR127 | |
A | ALA135 | |
A | GLN170 | |
B | GLY56 | |
B | GLY71 | |
B | ARG82 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Activating region 2 (AR2); probably contacts the N-terminus of RpoA => ECO:0000269|PubMed:8978616 |
Chain | Residue | Details |
A | GLU96 | |
B | GLU96 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Activating region 2 (AR2); probably contacts the N-terminus of RpoA => ECO:0000269|PubMed:15520470, ECO:0000269|PubMed:8978616 |
Chain | Residue | Details |
A | LYS101 | |
B | LYS101 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
Chain | Residue | Details |
A | LYS100 | |
B | LYS100 |