1ZQ9
Crystal structure of human Dimethyladenosine transferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000154 | biological_process | rRNA modification |
| A | 0000179 | molecular_function | rRNA (adenine-N6,N6-)-dimethyltransferase activity |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006364 | biological_process | rRNA processing |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0031167 | biological_process | rRNA methylation |
| A | 0032040 | cellular_component | small-subunit processome |
| A | 0032259 | biological_process | methylation |
| A | 0042274 | biological_process | ribosomal small subunit biogenesis |
| A | 0052909 | molecular_function | 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity |
| A | 2000234 | biological_process | positive regulation of rRNA processing |
| B | 0000154 | biological_process | rRNA modification |
| B | 0000179 | molecular_function | rRNA (adenine-N6,N6-)-dimethyltransferase activity |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005829 | cellular_component | cytosol |
| B | 0006364 | biological_process | rRNA processing |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0031167 | biological_process | rRNA methylation |
| B | 0032040 | cellular_component | small-subunit processome |
| B | 0032259 | biological_process | methylation |
| B | 0042274 | biological_process | ribosomal small subunit biogenesis |
| B | 0052909 | molecular_function | 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity |
| B | 2000234 | biological_process | positive regulation of rRNA processing |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE SAM A 4000 |
| Chain | Residue |
| A | GLN36 |
| A | GLY112 |
| A | ASP113 |
| A | VAL114 |
| A | ASN128 |
| A | LEU129 |
| A | PRO130 |
| A | MET154 |
| A | PHE196 |
| A | SER204 |
| A | HOH4166 |
| A | HIS37 |
| A | HOH4236 |
| A | HOH4282 |
| A | HOH4329 |
| A | ILE38 |
| A | GLY64 |
| A | GLY66 |
| A | CYS84 |
| A | GLU85 |
| A | LEU86 |
| A | LEU90 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAM B 4001 |
| Chain | Residue |
| B | HIS37 |
| B | GLY64 |
| B | GLY66 |
| B | CYS84 |
| B | GLU85 |
| B | LEU86 |
| B | LEU90 |
| B | GLY112 |
| B | ASP113 |
| B | VAL114 |
| B | ASN128 |
| B | LEU129 |
| B | PRO130 |
| B | TYR131 |
| B | ILE133 |
| B | PHE196 |
| B | HOH4125 |
| B | HOH4166 |
| B | HOH4189 |
| B | HOH4208 |
| B | HOH4394 |
Functional Information from PROSITE/UniProt
| site_id | PS01131 |
| Number of Residues | 28 |
| Details | RRNA_A_DIMETH Ribosomal RNA adenine dimethylases signature. VLEvGPGtGnMTvklLekakk...VvACElD |
| Chain | Residue | Details |
| A | VAL60-ASP87 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01026, ECO:0000269|Ref.9 |
| Chain | Residue | Details |
| A | HIS37 | |
| B | GLU85 | |
| B | ASP113 | |
| B | ASN128 | |
| A | LEU39 | |
| A | GLY64 | |
| A | GLU85 | |
| A | ASP113 | |
| A | ASN128 | |
| B | HIS37 | |
| B | LEU39 | |
| B | GLY64 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qam |
| Chain | Residue | Details |
| A | GLY64 | |
| A | GLU85 | |
| A | ASN128 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qam |
| Chain | Residue | Details |
| B | GLY64 | |
| B | GLU85 | |
| B | ASN128 |
