1ZPD
PYRUVATE DECARBOXYLASE FROM ZYMOMONAS MOBILIS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004737 | molecular_function | pyruvate decarboxylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004737 | molecular_function | pyruvate decarboxylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0046872 | molecular_function | metal ion binding |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004737 | molecular_function | pyruvate decarboxylase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0016829 | molecular_function | lyase activity |
| E | 0016831 | molecular_function | carboxy-lyase activity |
| E | 0019752 | biological_process | carboxylic acid metabolic process |
| E | 0030976 | molecular_function | thiamine pyrophosphate binding |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004737 | molecular_function | pyruvate decarboxylase activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0016829 | molecular_function | lyase activity |
| F | 0016831 | molecular_function | carboxy-lyase activity |
| F | 0019752 | biological_process | carboxylic acid metabolic process |
| F | 0030976 | molecular_function | thiamine pyrophosphate binding |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 601 |
| Chain | Residue |
| A | ASP440 |
| A | ASN467 |
| A | GLY469 |
| A | DPX600 |
| A | HOH611 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 601 |
| Chain | Residue |
| B | HOH611 |
| B | ASP440 |
| B | ASN467 |
| B | GLY469 |
| B | DPX600 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG E 601 |
| Chain | Residue |
| E | ASP440 |
| E | ASN467 |
| E | GLY469 |
| E | DPX600 |
| E | HOH611 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG F 601 |
| Chain | Residue |
| F | ASP440 |
| F | ASN467 |
| F | GLY469 |
| F | DPX600 |
| F | HOH611 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE DPX A 600 |
| Chain | Residue |
| A | ASP390 |
| A | GLY413 |
| A | HIS414 |
| A | ILE415 |
| A | GLY439 |
| A | ASP440 |
| A | GLY441 |
| A | SER442 |
| A | ASN467 |
| A | GLY469 |
| A | TYR470 |
| A | THR471 |
| A | ILE472 |
| A | GLU473 |
| A | MG601 |
| A | HOH611 |
| A | HOH612 |
| A | HOH769 |
| A | HOH1256 |
| B | ALA25 |
| B | GLY26 |
| B | GLU50 |
| B | VAL75 |
| B | HIS114 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CIT A 610 |
| Chain | Residue |
| A | ARG310 |
| A | ARG318 |
| A | PRO320 |
| A | SER321 |
| A | HOH709 |
| A | HOH746 |
| A | HOH789 |
| A | HOH1006 |
| A | HOH1049 |
| F | HIS150 |
| F | LYS153 |
| F | ARG157 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE DPX B 600 |
| Chain | Residue |
| A | ALA25 |
| A | GLY26 |
| A | GLU50 |
| A | VAL75 |
| A | HIS114 |
| B | ASP390 |
| B | GLY413 |
| B | HIS414 |
| B | ILE415 |
| B | GLY439 |
| B | ASP440 |
| B | GLY441 |
| B | SER442 |
| B | ASN467 |
| B | GLY469 |
| B | TYR470 |
| B | THR471 |
| B | ILE472 |
| B | GLU473 |
| B | MG601 |
| B | HOH611 |
| B | HOH612 |
| B | HOH842 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CIT B 610 |
| Chain | Residue |
| B | ARG310 |
| B | ARG318 |
| B | PRO320 |
| B | SER321 |
| B | HOH688 |
| B | HOH782 |
| B | HOH819 |
| B | HOH861 |
| B | HOH1111 |
| E | HIS150 |
| E | LYS153 |
| E | ARG157 |
| site_id | AC9 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE DPX E 600 |
| Chain | Residue |
| E | ASN467 |
| E | GLY469 |
| E | TYR470 |
| E | THR471 |
| E | ILE472 |
| E | GLU473 |
| E | MG601 |
| E | HOH611 |
| E | HOH612 |
| E | HOH874 |
| F | ALA25 |
| F | GLY26 |
| F | GLU50 |
| F | VAL75 |
| F | HIS114 |
| E | ASP390 |
| E | GLY413 |
| E | HIS414 |
| E | ILE415 |
| E | GLY439 |
| E | ASP440 |
| E | GLY441 |
| E | SER442 |
| site_id | BC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CIT E 610 |
| Chain | Residue |
| B | HIS150 |
| B | LYS153 |
| B | ARG157 |
| E | ARG310 |
| E | ARG318 |
| E | PRO320 |
| E | SER321 |
| E | HOH656 |
| E | HOH814 |
| E | HOH851 |
| E | HOH894 |
| E | HOH1113 |
| site_id | BC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE DPX F 600 |
| Chain | Residue |
| E | ALA25 |
| E | GLY26 |
| E | GLU50 |
| E | VAL75 |
| E | HIS114 |
| F | ASP390 |
| F | GLY413 |
| F | HIS414 |
| F | ILE415 |
| F | GLY439 |
| F | ASP440 |
| F | GLY441 |
| F | SER442 |
| F | ASN467 |
| F | GLY469 |
| F | TYR470 |
| F | THR471 |
| F | ILE472 |
| F | GLU473 |
| F | MG601 |
| F | HOH611 |
| F | HOH612 |
| F | HOH943 |
| F | HOH1240 |
| site_id | BC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CIT F 610 |
| Chain | Residue |
| A | HIS150 |
| A | LYS153 |
| A | ARG157 |
| F | ARG310 |
| F | ARG318 |
| F | PRO320 |
| F | SER321 |
| F | HOH712 |
| F | HOH793 |
| F | HOH885 |
| F | HOH920 |
| F | HOH962 |
Functional Information from PROSITE/UniProt
| site_id | PS00187 |
| Number of Residues | 20 |
| Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. FGyavgaPerrnIlMvGDGS |
| Chain | Residue | Details |
| A | PHE423-SER442 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 328 |
| Details | Region: {"description":"Thiamine pyrophosphate binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| F | THR545 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| A | THR545 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| B | THR545 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| E | THR545 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| A | GLU473 | |
| A | HIS113 | |
| A | HIS114 | |
| A | ASP27 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| B | GLU473 | |
| B | HIS113 | |
| B | HIS114 | |
| B | ASP27 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| E | GLU473 | |
| E | HIS113 | |
| E | HIS114 | |
| E | ASP27 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| F | GLU473 | |
| F | HIS113 | |
| F | HIS114 | |
| F | ASP27 |
