1ZNC
HUMAN CARBONIC ANHYDRASE IV
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004089 | molecular_function | carbonate dehydratase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005791 | cellular_component | rough endoplasmic reticulum |
| A | 0005793 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005802 | cellular_component | trans-Golgi network |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0009986 | cellular_component | cell surface |
| A | 0015701 | biological_process | bicarbonate transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016829 | molecular_function | lyase activity |
| A | 0030658 | cellular_component | transport vesicle membrane |
| A | 0030667 | cellular_component | secretory granule membrane |
| A | 0031526 | cellular_component | brush border membrane |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0098552 | cellular_component | side of membrane |
| B | 0004089 | molecular_function | carbonate dehydratase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005791 | cellular_component | rough endoplasmic reticulum |
| B | 0005793 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005802 | cellular_component | trans-Golgi network |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0009897 | cellular_component | external side of plasma membrane |
| B | 0009986 | cellular_component | cell surface |
| B | 0015701 | biological_process | bicarbonate transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0016829 | molecular_function | lyase activity |
| B | 0030658 | cellular_component | transport vesicle membrane |
| B | 0030667 | cellular_component | secretory granule membrane |
| B | 0031526 | cellular_component | brush border membrane |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0098552 | cellular_component | side of membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 601 |
| Chain | Residue |
| A | LEU198 |
| A | THR199 |
| A | TRP209 |
| A | ZN301 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS94 |
| A | HIS96 |
| A | HIS119 |
| A | THR199 |
| A | SO4601 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | HIS94 |
| B | HIS96 |
| B | HIS119 |
| B | THR199 |
| B | SO4701 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 701 |
| Chain | Residue |
| B | HIS119 |
| B | LEU198 |
| B | THR199 |
| B | TRP209 |
| B | ZN302 |
| site_id | CTA |
| Number of Residues | 5 |
| Details | ZINC COORDINATED BY HIS A 94, HIS A 96, AND HIS A 119. ALSO COORDINATED BY AN OXYGEN ON THE SULFATE GROUP. |
| Chain | Residue |
| A | HIS94 |
| A | HIS96 |
| A | HIS119 |
| A | ZN301 |
| A | SO4601 |
| site_id | CTB |
| Number of Residues | 5 |
| Details | ZINC COORDINATED BY HIS B 94, HIS B 96, AND HIS B 119. ALSO COORDINATED BY AN OXYGEN ON THE SULFATE GROUP. |
| Chain | Residue |
| B | SO4701 |
| B | HIS94 |
| B | HIS96 |
| B | HIS119 |
| B | ZN302 |
Functional Information from PROSITE/UniProt
| site_id | PS00162 |
| Number of Residues | 17 |
| Details | ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHsLdgehFamEMHIV |
| Chain | Residue | Details |
| A | SER105-VAL121 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:P00918 |
| Chain | Residue | Details |
| A | HIS64 | |
| B | HIS64 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:8942978 |
| Chain | Residue | Details |
| A | HIS94 | |
| A | HIS96 | |
| A | HIS119 | |
| B | HIS94 | |
| B | HIS96 | |
| B | HIS119 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00918 |
| Chain | Residue | Details |
| A | THR199 | |
| B | THR199 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | LIPID: GPI-anchor amidated serine => ECO:0000269|PubMed:7625839 |
| Chain | Residue | Details |
| A | SER259 | |
| B | SER259 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ca2 |
| Chain | Residue | Details |
| A | THR199 | |
| A | HIS64 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ca2 |
| Chain | Residue | Details |
| B | THR199 | |
| B | HIS64 |
