1ZLH
Crystal structure of the tick carboxypeptidase inhibitor in complex with bovine carboxypeptidase A
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004181 | molecular_function | metallocarboxypeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008270 | molecular_function | zinc ion binding |
B | 0004857 | molecular_function | enzyme inhibitor activity |
B | 0005575 | cellular_component | cellular_component |
B | 0005576 | cellular_component | extracellular region |
B | 0007596 | biological_process | blood coagulation |
B | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
B | 0010951 | biological_process | negative regulation of endopeptidase activity |
B | 0030414 | molecular_function | peptidase inhibitor activity |
B | 0035821 | biological_process | modulation of process of another organism |
B | 0044002 | biological_process | acquisition of nutrients from host |
B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 555 |
Chain | Residue |
A | HIS69 |
A | GLU72 |
A | HIS196 |
B | LEU74 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 666 |
Chain | Residue |
A | HIS120 |
B | ASN1 |
B | HOH79 |
B | HOH155 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ZN A 777 |
Chain | Residue |
A | HOH1117 |
A | HOH1216 |
A | ASP16 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ZN A 888 |
Chain | Residue |
A | HIS29 |
A | HOH1168 |
A | HOH1197 |
A | HOH1246 |
A | HOH1272 |
A | HOH1277 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ZN A 999 |
Chain | Residue |
A | HIS303 |
A | HOH1257 |
A | HOH1271 |
Functional Information from PROSITE/UniProt
site_id | PS00132 |
Number of Residues | 23 |
Details | CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PaIwIdlGiHSrEwITQatgvwF |
Chain | Residue | Details |
A | PRO60-PHE82 |
site_id | PS00133 |
Number of Residues | 11 |
Details | CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSYSQLLlYPY |
Chain | Residue | Details |
A | HIS196-TYR206 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01379 |
Chain | Residue | Details |
A | GLU270 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01379, ECO:0000269|PubMed:12431056, ECO:0007744|PDB:1IY7 |
Chain | Residue | Details |
A | HIS69 | |
A | GLU72 | |
A | HIS196 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12431056, ECO:0007744|PDB:1IY7 |
Chain | Residue | Details |
A | ARG127 | |
A | ASN144 | |
A | SER197 | |
A | TYR248 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1cbx |
Chain | Residue | Details |
A | ARG127 | |
A | GLU270 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1cbx |
Chain | Residue | Details |
A | ARG71 | |
A | GLU270 | |
A | ARG127 |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 171 |
Chain | Residue | Details |
A | HIS69 | metal ligand |
A | GLU72 | metal ligand |
A | ARG127 | electrostatic stabiliser, hydrogen bond donor |
A | HIS196 | metal ligand |
A | GLU270 | covalently attached, electrofuge, electrophile, hydrogen bond acceptor, hydrogen bond donor, nucleophile, proton acceptor, proton donor |