1ZL5

Crystal structure of Glu335Gln mutant of Clostridium botulinum neurotoxin E catalytic domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 601

Chain	Residue
A	ARG384

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 602

Chain	Residue
A	ALA152
A	GLU153
A	ASP155
A	GLU158

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 604

Chain	Residue
A	GLN335
A	ARG347

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 605

Chain	Residue
A	ILE398
A	ARG401

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site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 606

Chain	Residue
B	GLY126
B	ASP127
B	ARG167

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site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 607

Chain	Residue
A	GLY126
A	ASP127

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site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 608

Chain	Residue
A	ARG393
B	ALA312

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLMHELIHSL

Chain	Residue	Details
A	THR208-LEU217

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15157097","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"1T3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZKX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZN3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FFZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"1T3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZKX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZN3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FFZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1i1e

Chain	Residue	Details
A	TYR350
A	ARG347
A	GLU250

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1i1e

Chain	Residue	Details
B	TYR350
B	ARG347
B	GLU250

---