1ZKW

Crystal structure of Arg347Ala mutant of botulinum neurotoxin E catalytic domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 422

Chain	Residue
A	HIS211
A	HIS215
A	GLU250
A	HOH745

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 822

Chain	Residue
B	HIS211
B	HIS215
B	GLU250
B	TYR350
B	HOH920

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 575

Chain	Residue
A	ARG401

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 576

Chain	Residue
A	LYS224

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site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 577

Chain	Residue
B	ASN364

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site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 578

Chain	Residue
A	ARG393
B	ALA312

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site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 579

Chain	Residue
A	GLY126

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site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 580

Chain	Residue
A	SER264

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site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 581

Chain	Residue
A	ASN7
A	ASN361

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLMHELIHSL

Chain	Residue	Details
A	THR208-LEU217

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15157097","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"1T3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZKX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZN3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FFZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"1T3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZKX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZN3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FFZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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