1ZKQ
Crystal structure of mouse thioredoxin reductase type 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000305 | biological_process | response to oxygen radical |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0007507 | biological_process | heart development |
| A | 0010035 | biological_process | obsolete response to inorganic substance |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0030097 | biological_process | hemopoiesis |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE FAD A 600 |
| Chain | Residue |
| A | GLY46 |
| A | LYS94 |
| A | LYS158 |
| A | ALA159 |
| A | ALA187 |
| A | THR188 |
| A | GLY189 |
| A | SER208 |
| A | TYR228 |
| A | VAL229 |
| A | ARG318 |
| A | SER49 |
| A | THR324 |
| A | LEU325 |
| A | GLY358 |
| A | ASP359 |
| A | GLU366 |
| A | LEU367 |
| A | THR368 |
| A | PRO369 |
| A | PHE400 |
| A | HIS497 |
| A | GLY50 |
| A | HOH605 |
| A | HOH617 |
| A | HOH622 |
| A | ASP69 |
| A | TYR70 |
| A | GLY84 |
| A | THR85 |
| A | CYS86 |
| A | CYS91 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP |
| Chain | Residue | Details |
| A | GLY83-PRO93 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS497 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP41 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337 |
| Chain | Residue | Details |
| A | LYS79 | |
| A | LYS175 | |
| A | LYS329 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Cysteinyl-selenocysteine (Cys-Sec) => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS522 | |
| A | CYS523 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | CYS86 | |
| A | CYS91 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | HIS497 | |
| A | GLU502 |
