Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NAP A 755 |
| Chain | Residue |
| A | GLY26 |
| A | ASN167 |
| A | GLN188 |
| A | PHE214 |
| A | SER215 |
| A | PRO216 |
| A | VAL217 |
| A | ARG218 |
| A | LYS219 |
| A | GLY220 |
| A | ALA246 |
| A | SER27 |
| A | VAL261 |
| A | PRO262 |
| A | LYS263 |
| A | SER264 |
| A | ARG269 |
| A | ASN273 |
| A | HOH788 |
| A | HOH797 |
| A | HOH863 |
| A | HOH878 |
| A | ALA28 |
| A | HOH889 |
| A | HOH922 |
| A | ASP30 |
| A | ASP53 |
| A | TYR58 |
| A | LYS87 |
| A | HIS120 |
| A | SER166 |
| site_id | AC2 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NAP B 1755 |
| Chain | Residue |
| B | GLY26 |
| B | SER27 |
| B | ALA28 |
| B | ASP30 |
| B | ASP53 |
| B | TYR58 |
| B | LYS87 |
| B | HIS120 |
| B | SER166 |
| B | ASN167 |
| B | GLN188 |
| B | PHE214 |
| B | SER215 |
| B | PRO216 |
| B | VAL217 |
| B | ARG218 |
| B | LYS219 |
| B | GLY220 |
| B | ALA246 |
| B | PRO262 |
| B | LYS263 |
| B | SER264 |
| B | TYR265 |
| B | ARG269 |
| B | ASN273 |
| B | HOH1781 |
| B | HOH1832 |
| B | HOH1851 |
| B | HOH1891 |
| B | HOH1893 |
| B | HOH1908 |
| B | HOH1927 |
| B | HOH1937 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeeslklglTKAIGVSNF |
| Chain | Residue | Details |
| A | MET151-PHE168 | |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHFDTAaaygsEqaLG |
| Chain | Residue | Details |
| A | GLY48-GLY65 | |
