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1ZFS

Solution structure of S100A1 bound to calcium

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0008016biological_processregulation of heart contraction
A0008284biological_processpositive regulation of cell population proliferation
A0016529cellular_componentsarcoplasmic reticulum
A0030018cellular_componentZ disc
A0031430cellular_componentM band
A0031672cellular_componentA band
A0031674cellular_componentI band
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0044548molecular_functionS100 protein binding
A0046872molecular_functionmetal ion binding
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050786molecular_functionRAGE receptor binding
A0051117molecular_functionATPase binding
A1903672biological_processpositive regulation of sprouting angiogenesis
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0008016biological_processregulation of heart contraction
B0008284biological_processpositive regulation of cell population proliferation
B0016529cellular_componentsarcoplasmic reticulum
B0030018cellular_componentZ disc
B0031430cellular_componentM band
B0031672cellular_componentA band
B0031674cellular_componentI band
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0044548molecular_functionS100 protein binding
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050786molecular_functionRAGE receptor binding
B0051117molecular_functionATPase binding
B1903672biological_processpositive regulation of sprouting angiogenesis
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 101
ChainResidue
BLEU61
BASP62
BASP66
BGLU68
BVAL69
BGLU73

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 102
ChainResidue
BLEU28
BGLU32
BSER19
BASP24
BLYS27

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 103
ChainResidue
ALEU61
AASP62
AASP66
AGLU68
AVAL69
AGLU73

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 104
ChainResidue
ASER19
AASP24
ALYS27
AGLU32

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DENGDGEVDfqEF
ChainResidueDetails
AASP62-PHE74

site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. IMkeLDengDgevDFqEFvvLV
ChainResidueDetails
AILE57-VAL78

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:16169012, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:19452629
ChainResidueDetails
ALEU28
ALEU33
BLEU28
BLEU33

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:16169012, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:19452629
ChainResidueDetails
AGLU63
BPHE74
AGLY65
AGLY67
AVAL69
APHE74
BGLU63
BGLY65
BGLY67
BVAL69

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P23297
ChainResidueDetails
AASN86
BASN86

218853

PDB entries from 2024-04-24

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