1ZFS

Solution structure of S100A1 bound to calcium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0008016	biological_process	regulation of heart contraction
A	0016529	cellular_component	sarcoplasmic reticulum
A	0030018	cellular_component	Z disc
A	0031430	cellular_component	M band
A	0031672	cellular_component	A band
A	0031674	cellular_component	I band
A	0042802	molecular_function	identical protein binding
A	0044548	molecular_function	S100 protein binding
A	0048306	molecular_function	calcium-dependent protein binding
A	1901387	biological_process	positive regulation of voltage-gated calcium channel activity
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0008016	biological_process	regulation of heart contraction
B	0016529	cellular_component	sarcoplasmic reticulum
B	0030018	cellular_component	Z disc
B	0031430	cellular_component	M band
B	0031672	cellular_component	A band
B	0031674	cellular_component	I band
B	0042802	molecular_function	identical protein binding
B	0044548	molecular_function	S100 protein binding
B	0048306	molecular_function	calcium-dependent protein binding
B	1901387	biological_process	positive regulation of voltage-gated calcium channel activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 101

Chain	Residue
B	LEU61
B	ASP62
B	ASP66
B	GLU68
B	VAL69
B	GLU73

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 102

Chain	Residue
B	LEU28
B	GLU32
B	SER19
B	ASP24
B	LYS27

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 103

Chain	Residue
A	LEU61
A	ASP62
A	ASP66
A	GLU68
A	VAL69
A	GLU73

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 104

Chain	Residue
A	SER19
A	ASP24
A	LYS27
A	GLU32

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DENGDGEVDfqEF

Chain	Residue	Details
A	ASP62-PHE74

---

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. IMkeLDengDgevDFqEFvvLV

Chain	Residue	Details
A	ILE57-VAL78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	70
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16169012","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18650434","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19452629","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16169012","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18650434","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19452629","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P23297","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---