1ZFJ

INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH; EC 1.1.1.205) FROM STREPTOCOCCUS PYOGENES

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006177	biological_process	GMP biosynthetic process
A	0006183	biological_process	GTP biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE IMP A 500

Chain	Residue
A	GLY366
A	SER367
A	TYR390
A	GLY392
A	MSE393
A	GLY394
A	GLU421
A	GLY422
A	HOH580
A	HOH636
A	ALA51
A	GLY307
A	SER308
A	ILE309
A	CYS310
A	ASP343
A	GLY345
A	MSE364

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site_id	ASC
Number of Residues	1
Details	ACTIVE SITE CYSTEINE

Chain	Residue
A	CYS310

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Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. VKVGIGpGSICtT

Chain	Residue	Details
A	VAL300-THR312

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	CYS310

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	ARG406

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	ASP253
A	GLY303
A	GLU421
A	GLU475
A	SER476
A	HIS477

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site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	GLY305
A	GLY307
A	CYS310

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site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000269|PubMed:10200156

Chain	Residue	Details
A	SER308

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site_id	SWS_FT_FI6
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	ASP343
A	GLY366
A	TYR390

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
A	LYS135

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