1ZED

Alkaline phosphatase from human placenta in complex with p-nitrophenyl-phosphonate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004035	molecular_function	alkaline phosphatase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0008270	molecular_function	zinc ion binding
A	0009986	cellular_component	cell surface
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0046872	molecular_function	metal ion binding
A	0098552	cellular_component	side of membrane

Functional Information from PROSITE/UniProt

site_id	PS00123
Number of Residues	9
Details	ALKALINE_PHOSPHATASE Alkaline phosphatase active site. VpDSGATAT

Chain	Residue	Details
A	VAL89-THR97

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphoserine intermediate => ECO:0000255|PROSITE-ProRule:PRU10042

Chain	Residue	Details
A	SER92

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site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:11124260, ECO:0000269|PubMed:15946677, ECO:0000269|PubMed:16815919, ECO:0000269|PubMed:20693656

Chain	Residue	Details
A	ASP42
A	SER92
A	SER155
A	GLU311
A	ASP316
A	HIS320
A	ASP357
A	HIS358
A	HIS432

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P05186

Chain	Residue	Details
A	GLU216
A	PHE269
A	GLU270
A	ASP285

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site_id	SWS_FT_FI4
Number of Residues	1
Details	LIPID: GPI-anchor amidated aspartate => ECO:0000269|PubMed:2153284

Chain	Residue	Details
A	ASP484

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15946677, ECO:0000269|PubMed:16815919, ECO:0000269|PubMed:20693656

Chain	Residue	Details
A	ASN122
A	ASN249

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1alk

Chain	Residue	Details
A	SER92
A	ARG166

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