1ZDR
DHFR from Bacillus Stearothermophilus
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006545 | biological_process | glycine biosynthetic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0050661 | molecular_function | NADP binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006545 | biological_process | glycine biosynthetic process |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046452 | biological_process | dihydrofolate metabolic process |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046655 | biological_process | folic acid metabolic process |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 3482 |
Chain | Residue |
A | ARG111 |
A | HOH3522 |
A | HOH3548 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 A 3483 |
Chain | Residue |
A | HOH3557 |
A | HOH3644 |
A | GLY43 |
A | ARG44 |
A | LYS45 |
A | THR46 |
A | GLY98 |
A | HOH3510 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 3484 |
Chain | Residue |
A | LYS32 |
A | ARG57 |
A | HOH3498 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 B 3485 |
Chain | Residue |
B | PHE31 |
B | HOH3493 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 3486 |
Chain | Residue |
A | PHE31 |
A | LEU54 |
A | HOH3516 |
A | HOH3619 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL B 1901 |
Chain | Residue |
B | GLY43 |
B | ARG44 |
B | LYS45 |
B | THR46 |
B | GLY97 |
B | GLY98 |
B | ALA99 |
B | GLU100 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGkdnrLPWhlpa.DlayFkrvT |
Chain | Residue | Details |
A | VAL13-THR35 |