1ZD2

Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-ethanoic acid complex

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0000287	molecular_function	magnesium ion binding
P	0001558	biological_process	regulation of cell growth
P	0003824	molecular_function	catalytic activity
P	0004301	molecular_function	epoxide hydrolase activity
P	0005737	cellular_component	cytoplasm
P	0005777	cellular_component	peroxisome
P	0005782	cellular_component	peroxisomal matrix
P	0005829	cellular_component	cytosol
P	0006629	biological_process	lipid metabolic process
P	0009636	biological_process	response to toxic substance
P	0010628	biological_process	positive regulation of gene expression
P	0015643	molecular_function	toxic substance binding
P	0016311	biological_process	dephosphorylation
P	0016787	molecular_function	hydrolase activity
P	0016791	molecular_function	phosphatase activity
P	0033885	molecular_function	10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
P	0042577	molecular_function	lipid phosphatase activity
P	0042632	biological_process	cholesterol homeostasis
P	0042803	molecular_function	protein homodimerization activity
P	0046272	biological_process	stilbene catabolic process
P	0046839	biological_process	phospholipid dephosphorylation
P	0046872	molecular_function	metal ion binding
P	0052642	molecular_function	lysophosphatidic acid phosphatase activity
P	0070062	cellular_component	extracellular exosome
P	0090181	biological_process	regulation of cholesterol metabolic process
P	0097176	biological_process	epoxide metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG P 800

Chain	Residue
P	ASP9
P	ASP11
P	ASP184
P	ASP185
P	PO4900

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 P 900

Chain	Residue
P	LYS160
P	MG800
P	ASP9
P	ASP11
P	THR123
P	ASN124

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NC3 P 700

Chain	Residue
P	PHE265
P	ASP333
P	TRP334
P	MET337
P	TYR381
P	MET418
P	TYR465
P	VAL497
P	HIS523

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	272
Details	Domain: {"description":"AB hydrolase-1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"15096040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16322563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19746975","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19969453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20934334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15096040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16322563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19746975","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19969453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20934334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"15096040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16322563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19746975","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19969453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20934334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15096040","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15096040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16322563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19746975","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19969453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20934334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P34914","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P34914","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P34914","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Lipidation: {"description":"S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine","evidences":[{"source":"PubMed","id":"21164107","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1b6g

Chain	Residue	Details
P	HIS523
P	ASP495
P	ASP333

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1b6g

Chain	Residue	Details
P	THR123
P	LYS160

---