1ZCB
Crystal structure of G alpha 13 in complex with GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001525 | biological_process | angiogenesis |
| A | 0001569 | biological_process | branching involved in blood vessel morphogenesis |
| A | 0001664 | molecular_function | G protein-coupled receptor binding |
| A | 0001701 | biological_process | in utero embryonic development |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005834 | cellular_component | heterotrimeric G-protein complex |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| A | 0007266 | biological_process | Rho protein signal transduction |
| A | 0008217 | biological_process | regulation of blood pressure |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0010762 | biological_process | regulation of fibroblast migration |
| A | 0016020 | cellular_component | membrane |
| A | 0019001 | molecular_function | guanyl nucleotide binding |
| A | 0030154 | biological_process | cell differentiation |
| A | 0030168 | biological_process | platelet activation |
| A | 0030334 | biological_process | regulation of cell migration |
| A | 0031526 | cellular_component | brush border membrane |
| A | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| A | 0031752 | molecular_function | D5 dopamine receptor binding |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0042470 | cellular_component | melanosome |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0098794 | cellular_component | postsynapse |
| A | 0150052 | biological_process | regulation of postsynapse assembly |
| A | 0160221 | biological_process | Rho-activating G protein-coupled receptor signaling pathway |
| A | 1904706 | biological_process | negative regulation of vascular associated smooth muscle cell proliferation |
| A | 1904753 | biological_process | negative regulation of vascular associated smooth muscle cell migration |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDP A 378 |
| Chain | Residue |
| A | GLU58 |
| A | ARG200 |
| A | ASN291 |
| A | LYS292 |
| A | ASP294 |
| A | LEU295 |
| A | THR348 |
| A | ALA349 |
| A | ILE350 |
| A | HOH386 |
| A | HOH392 |
| A | SER59 |
| A | HOH399 |
| A | HOH417 |
| A | HOH424 |
| A | GLY60 |
| A | LYS61 |
| A | SER62 |
| A | THR63 |
| A | GLU172 |
| A | LEU197 |
| A | LEU198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 13 |
| Details | Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16388592","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18940608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CX7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18940608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CX6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18940608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CX7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q14344","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bh2 |
| Chain | Residue | Details |
| A | GLU58 | |
| A | ARG200 | |
| A | THR203 |
