1ZCB

Crystal structure of G alpha 13 in complex with GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0001569	biological_process	branching involved in blood vessel morphogenesis
A	0001664	molecular_function	G protein-coupled receptor binding
A	0001701	biological_process	in utero embryonic development
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005834	cellular_component	heterotrimeric G-protein complex
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0007266	biological_process	Rho protein signal transduction
A	0008217	biological_process	regulation of blood pressure
A	0008360	biological_process	regulation of cell shape
A	0010762	biological_process	regulation of fibroblast migration
A	0016020	cellular_component	membrane
A	0019001	molecular_function	guanyl nucleotide binding
A	0030154	biological_process	cell differentiation
A	0030168	biological_process	platelet activation
A	0031526	cellular_component	brush border membrane
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
A	0031752	molecular_function	D5 dopamine receptor binding
A	0035556	biological_process	intracellular signal transduction
A	0042470	cellular_component	melanosome
A	0046872	molecular_function	metal ion binding
A	0098794	cellular_component	postsynapse
A	0150052	biological_process	regulation of postsynapse assembly
A	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
A	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE GDP A 378

Chain	Residue
A	GLU58
A	ARG200
A	ASN291
A	LYS292
A	ASP294
A	LEU295
A	THR348
A	ALA349
A	ILE350
A	HOH386
A	HOH392
A	SER59
A	HOH399
A	HOH417
A	HOH424
A	GLY60
A	LYS61
A	SER62
A	THR63
A	GLU172
A	LEU197
A	LEU198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16388592, ECO:0000269|PubMed:18940608, ECO:0007744|PDB:1ZCB, ECO:0007744|PDB:3CX6, ECO:0007744|PDB:3CX7

Chain	Residue	Details
A	GLU58
A	LEU197
A	ASN291
A	ALA349

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:18940608, ECO:0007744|PDB:3CX6

Chain	Residue	Details
A	SER62
A	THR203

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:18940608, ECO:0007744|PDB:3CX7

Chain	Residue	Details
A	SER173

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q14344

Chain	Residue	Details
A	THR203

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site_id	SWS_FT_FI5
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q14344

Chain	Residue	Details
A	GLU29
A	CYS18

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1bh2

Chain	Residue	Details
A	GLU58
A	ARG200
A	THR203

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