1ZBK
Recognition of specific peptide sequences by signalling protein from sheep mammary gland (SPS-40): Crystal structure of the complex of SPS-40 with a peptide Trp-Pro-Trp at 2.9A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006032 | biological_process | chitin catabolic process |
| A | 0006915 | biological_process | apoptotic process |
| A | 0006954 | biological_process | inflammatory response |
| A | 0007250 | biological_process | activation of NF-kappaB-inducing kinase activity |
| A | 0008061 | molecular_function | chitin binding |
| A | 0009612 | biological_process | response to mechanical stimulus |
| A | 0010800 | biological_process | positive regulation of peptidyl-threonine phosphorylation |
| A | 0030246 | molecular_function | carbohydrate binding |
| A | 0030324 | biological_process | lung development |
| A | 0032757 | biological_process | positive regulation of interleukin-8 production |
| A | 0034612 | biological_process | response to tumor necrosis factor |
| A | 0045766 | biological_process | positive regulation of angiogenesis |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0051897 | biological_process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| A | 0070555 | biological_process | response to interleukin-1 |
| A | 0070741 | biological_process | response to interleukin-6 |
| A | 0071356 | biological_process | cellular response to tumor necrosis factor |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 360 |
| Details | Domain: {"description":"GH18","evidences":[{"source":"PROSITE-ProRule","id":"PRU01258","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Region: {"description":"Important for AKT1 activation and IL8 production","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01258","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16859926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17188513","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1itx |
| Chain | Residue | Details |
| A | LEU119 | |
| A | ASP115 |
