Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1ZBD

STRUCTURAL BASIS OF RAB EFFECTOR SPECIFICITY: CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAB3A COMPLEXED WITH THE EFFECTOR DOMAIN OF RABPHILIN-3A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001669	cellular_component	acrosomal vesicle
A	0001671	molecular_function	ATPase activator activity
A	0001778	biological_process	plasma membrane repair
A	0003016	biological_process	respiratory system process
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005764	cellular_component	lysosome
A	0005768	cellular_component	endosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006887	biological_process	exocytosis
A	0007005	biological_process	mitochondrion organization
A	0007274	biological_process	neuromuscular synaptic transmission
A	0007409	biological_process	axonogenesis
A	0008021	cellular_component	synaptic vesicle
A	0009791	biological_process	post-embryonic development
A	0010807	biological_process	regulation of synaptic vesicle priming
A	0014059	biological_process	regulation of dopamine secretion
A	0015031	biological_process	protein transport
A	0016079	biological_process	synaptic vesicle exocytosis
A	0016188	biological_process	synaptic vesicle maturation
A	0016787	molecular_function	hydrolase activity
A	0017156	biological_process	calcium-ion regulated exocytosis
A	0017157	biological_process	regulation of exocytosis
A	0030073	biological_process	insulin secretion
A	0030133	cellular_component	transport vesicle
A	0030141	cellular_component	secretory granule
A	0030324	biological_process	lung development
A	0030424	cellular_component	axon
A	0030672	cellular_component	synaptic vesicle membrane
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0030742	molecular_function	GTP-dependent protein binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0031489	molecular_function	myosin V binding
A	0031630	biological_process	regulation of synaptic vesicle fusion to presynaptic active zone membrane
A	0032418	biological_process	lysosome localization
A	0032482	biological_process	Rab protein signal transduction
A	0032991	cellular_component	protein-containing complex
A	0036465	biological_process	synaptic vesicle recycling
A	0043195	cellular_component	terminal bouton
A	0045055	biological_process	regulated exocytosis
A	0048172	biological_process	regulation of short-term neuronal synaptic plasticity
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0048489	biological_process	synaptic vesicle transport
A	0048786	cellular_component	presynaptic active zone
A	0048790	biological_process	maintenance of presynaptic active zone structure
A	0050975	biological_process	sensory perception of touch
A	0051021	molecular_function	GDP-dissociation inhibitor binding
A	0051117	molecular_function	ATPase binding
A	0051602	biological_process	response to electrical stimulus
A	0051649	biological_process	establishment of localization in cell
A	0060478	biological_process	acrosomal vesicle exocytosis
A	0061670	biological_process	evoked neurotransmitter secretion
A	0097091	biological_process	synaptic vesicle clustering
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0099161	biological_process	regulation of presynaptic dense core granule exocytosis
A	1903307	biological_process	positive regulation of regulated secretory pathway
A	1905684	biological_process	regulation of plasma membrane repair
A	2000300	biological_process	regulation of synaptic vesicle exocytosis
B	0006886	biological_process	intracellular protein transport
B	0031267	molecular_function	small GTPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 300

Chain	Residue
B	CYS114
B	CYS137
B	CYS140
B	CYS111

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 301

Chain	Residue
B	CYS94
B	CYS97
B	CYS119
B	CYS122

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 302

Chain	Residue
A	THR36
A	THR54
A	GTP303

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GTP A 303

Chain	Residue
A	ASN30
A	SER31
A	SER32
A	VAL33
A	GLY34
A	LYS35
A	THR36
A	SER37
A	THR48
A	PRO49
A	ALA50
A	PHE51
A	SER53
A	THR54
A	GLY80
A	ASN135
A	LYS136
A	ASP138
A	MSE139
A	SER165
A	ALA166
A	LYS167
A	MG302

site_id	ZN1
Number of Residues	4
Details	ZN-BINDING RESIDUES FOR ZN 301

Chain	Residue
B	CYS94
B	CYS97
B	CYS119
B	CYS122

site_id	ZN2
Number of Residues	4
Details	ZN-BINDING RESIDUES FOR ZN 300

Chain	Residue
B	CYS111
B	CYS114
B	CYS137
B	CYS140

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"10025402","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZBD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"10025402","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZBD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10025402","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZBD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10025402","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10196122","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RAB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10196122","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3RAB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P20336","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00091","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	LEU81

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	SER32

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)