1ZBD
STRUCTURAL BASIS OF RAB EFFECTOR SPECIFICITY: CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAB3A COMPLEXED WITH THE EFFECTOR DOMAIN OF RABPHILIN-3A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001669 | cellular_component | acrosomal vesicle |
| A | 0001671 | molecular_function | ATPase activator activity |
| A | 0001778 | biological_process | plasma membrane repair |
| A | 0003016 | biological_process | respiratory system process |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005764 | cellular_component | lysosome |
| A | 0005768 | cellular_component | endosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006887 | biological_process | exocytosis |
| A | 0007005 | biological_process | mitochondrion organization |
| A | 0007274 | biological_process | neuromuscular synaptic transmission |
| A | 0007409 | biological_process | axonogenesis |
| A | 0008021 | cellular_component | synaptic vesicle |
| A | 0009791 | biological_process | post-embryonic development |
| A | 0010807 | biological_process | regulation of synaptic vesicle priming |
| A | 0014059 | biological_process | regulation of dopamine secretion |
| A | 0015031 | biological_process | protein transport |
| A | 0016079 | biological_process | synaptic vesicle exocytosis |
| A | 0016188 | biological_process | synaptic vesicle maturation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017156 | biological_process | calcium-ion regulated exocytosis |
| A | 0017157 | biological_process | regulation of exocytosis |
| A | 0030073 | biological_process | insulin secretion |
| A | 0030133 | cellular_component | transport vesicle |
| A | 0030141 | cellular_component | secretory granule |
| A | 0030324 | biological_process | lung development |
| A | 0030424 | cellular_component | axon |
| A | 0030672 | cellular_component | synaptic vesicle membrane |
| A | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| A | 0030742 | molecular_function | GTP-dependent protein binding |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031489 | molecular_function | myosin V binding |
| A | 0031630 | biological_process | regulation of synaptic vesicle fusion to presynaptic active zone membrane |
| A | 0032418 | biological_process | lysosome localization |
| A | 0032482 | biological_process | Rab protein signal transduction |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0036465 | biological_process | synaptic vesicle recycling |
| A | 0043195 | cellular_component | terminal bouton |
| A | 0045055 | biological_process | regulated exocytosis |
| A | 0048172 | biological_process | regulation of short-term neuronal synaptic plasticity |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0048489 | biological_process | synaptic vesicle transport |
| A | 0048786 | cellular_component | presynaptic active zone |
| A | 0048790 | biological_process | maintenance of presynaptic active zone structure |
| A | 0050975 | biological_process | sensory perception of touch |
| A | 0051021 | molecular_function | GDP-dissociation inhibitor binding |
| A | 0051117 | molecular_function | ATPase binding |
| A | 0051602 | biological_process | response to electrical stimulus |
| A | 0060478 | biological_process | acrosomal vesicle exocytosis |
| A | 0061670 | biological_process | evoked neurotransmitter secretion |
| A | 0097091 | biological_process | synaptic vesicle clustering |
| A | 0098793 | cellular_component | presynapse |
| A | 0098794 | cellular_component | postsynapse |
| A | 0099161 | biological_process | regulation of presynaptic dense core granule exocytosis |
| A | 1903307 | biological_process | positive regulation of regulated secretory pathway |
| A | 1905684 | biological_process | regulation of plasma membrane repair |
| A | 2000300 | biological_process | regulation of synaptic vesicle exocytosis |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0031267 | molecular_function | small GTPase binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 300 |
| Chain | Residue |
| B | CYS114 |
| B | CYS137 |
| B | CYS140 |
| B | CYS111 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| B | CYS94 |
| B | CYS97 |
| B | CYS119 |
| B | CYS122 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 302 |
| Chain | Residue |
| A | THR36 |
| A | THR54 |
| A | GTP303 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE GTP A 303 |
| Chain | Residue |
| A | ASN30 |
| A | SER31 |
| A | SER32 |
| A | VAL33 |
| A | GLY34 |
| A | LYS35 |
| A | THR36 |
| A | SER37 |
| A | THR48 |
| A | PRO49 |
| A | ALA50 |
| A | PHE51 |
| A | SER53 |
| A | THR54 |
| A | GLY80 |
| A | ASN135 |
| A | LYS136 |
| A | ASP138 |
| A | MSE139 |
| A | SER165 |
| A | ALA166 |
| A | LYS167 |
| A | MG302 |
| site_id | ZN1 |
| Number of Residues | 4 |
| Details | ZN-BINDING RESIDUES FOR ZN 301 |
| Chain | Residue |
| B | CYS94 |
| B | CYS97 |
| B | CYS119 |
| B | CYS122 |
| site_id | ZN2 |
| Number of Residues | 4 |
| Details | ZN-BINDING RESIDUES FOR ZN 300 |
| Chain | Residue |
| B | CYS111 |
| B | CYS114 |
| B | CYS137 |
| B | CYS140 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"10025402","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZBD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"10025402","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZBD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10025402","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZBD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10025402","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10196122","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RAB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10196122","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3RAB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P20336","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00091","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | LEU81 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | SER32 |
