1Z93
Human Carbonic Anhydrase III:Structural and Kinetic study of Catalysis and Proton Transfer.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003009 | biological_process | skeletal muscle contraction |
| A | 0004089 | molecular_function | carbonate dehydratase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0009617 | biological_process | response to bacterium |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0030017 | cellular_component | sarcomere |
| A | 0032869 | biological_process | cellular response to insulin stimulus |
| A | 0033993 | biological_process | response to lipid |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0044320 | biological_process | cellular response to leptin stimulus |
| A | 0045471 | biological_process | response to ethanol |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071456 | biological_process | cellular response to hypoxia |
| A | 0097305 | biological_process | response to alcohol |
| A | 0097421 | biological_process | liver regeneration |
| A | 1903427 | biological_process | negative regulation of reactive oxygen species biosynthetic process |
| A | 1903751 | biological_process | negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 268 |
| Chain | Residue |
| A | HIS94 |
| A | HIS96 |
| A | HIS119 |
| A | THR199 |
| A | HOH269 |
Functional Information from PROSITE/UniProt
| site_id | PS00162 |
| Number of Residues | 17 |
| Details | ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdgvkYaaELHLV |
| Chain | Residue | Details |
| A | SER105-VAL121 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16042381, ECO:0000269|PubMed:17427958 |
| Chain | Residue | Details |
| A | LEU95 | |
| A | TRP97 | |
| A | LEU120 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00918 |
| Chain | Residue | Details |
| A | THR200 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P07450 |
| Chain | Residue | Details |
| A | LYS3 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P14141 |
| Chain | Residue | Details |
| A | PRO30 | |
| A | LEU44 | |
| A | VAL49 | |
| A | TYR51 | |
| A | ALA56 | |
| A | ASP221 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P14141 |
| Chain | Residue | Details |
| A | TYR74 | |
| A | PHE131 | |
| A | VAL218 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P14141 |
| Chain | Residue | Details |
| A | ASN129 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P16015 |
| Chain | Residue | Details |
| A | LYS178 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: S-glutathionyl cysteine => ECO:0000250|UniProtKB:P14141 |
| Chain | Residue | Details |
| A | LEU184 | |
| A | ARG189 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ca2 |
| Chain | Residue | Details |
| A | THR199 | |
| A | LYS64 |
