1Z7X

X-ray structure of human ribonuclease inhibitor complexed with ribonuclease I

Functional Information from GO Data

Chain	GOid	namespace	contents
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005886	cellular_component	plasma membrane
W	0006402	biological_process	mRNA catabolic process
W	0008428	molecular_function	ribonuclease inhibitor activity
W	0016477	biological_process	cell migration
W	0030027	cellular_component	lamellipodium
W	0032311	cellular_component	angiogenin-PRI complex
W	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
W	0036416	biological_process	tRNA stabilization
W	0045765	biological_process	regulation of angiogenesis
W	0070062	cellular_component	extracellular exosome
X	0003676	molecular_function	nucleic acid binding
X	0004518	molecular_function	nuclease activity
X	0004519	molecular_function	endonuclease activity
X	0004522	molecular_function	ribonuclease A activity
X	0004540	molecular_function	RNA nuclease activity
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0016787	molecular_function	hydrolase activity
X	0016829	molecular_function	lyase activity
X	0050830	biological_process	defense response to Gram-positive bacterium
X	0051607	biological_process	defense response to virus
X	0070062	cellular_component	extracellular exosome
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005886	cellular_component	plasma membrane
Y	0006402	biological_process	mRNA catabolic process
Y	0008428	molecular_function	ribonuclease inhibitor activity
Y	0016477	biological_process	cell migration
Y	0030027	cellular_component	lamellipodium
Y	0032311	cellular_component	angiogenin-PRI complex
Y	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
Y	0036416	biological_process	tRNA stabilization
Y	0045765	biological_process	regulation of angiogenesis
Y	0070062	cellular_component	extracellular exosome
Z	0003676	molecular_function	nucleic acid binding
Z	0004518	molecular_function	nuclease activity
Z	0004519	molecular_function	endonuclease activity
Z	0004522	molecular_function	ribonuclease A activity
Z	0004540	molecular_function	RNA nuclease activity
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0016787	molecular_function	hydrolase activity
Z	0016829	molecular_function	lyase activity
Z	0050830	biological_process	defense response to Gram-positive bacterium
Z	0051607	biological_process	defense response to virus
Z	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CIT X 900

Chain	Residue
W	TYR434
X	LYS41
X	VAL118
X	HIS119
X	PHE120
W	ASP435
W	SER460
W	HOH519
X	ARG4
X	LYS7
X	PHE8
X	GLN11
X	HIS12

---

Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF

Chain	Residue	Details
X	CYS40-PHE46

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"description":"Proton donor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; partial","evidences":[{"source":"PubMed","id":"3202829","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"3202829","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	56
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	54
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	56
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	54
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	56
Details	Repeat: {"description":"LRR 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	54
Details	Repeat: {"description":"LRR 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	56
Details	Repeat: {"description":"LRR 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	54
Details	Repeat: {"description":"LRR 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	56
Details	Repeat: {"description":"LRR 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	54
Details	Repeat: {"description":"LRR 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	56
Details	Repeat: {"description":"LRR 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	54
Details	Repeat: {"description":"LRR 12"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	56
Details	Repeat: {"description":"LRR 13"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	54
Details	Repeat: {"description":"LRR 14"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	56
Details	Repeat: {"description":"LRR 15"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	18
Details	Region: {"description":"2 X 5 AA tandem repeats of S-L-D-I-Q"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
X	PHE120
X	HIS119
X	HIS12
X	LYS41

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
Z	PHE120
Z	HIS119
Z	HIS12
Z	LYS41

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
X	HIS119
X	HIS12
X	LYS41

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
Z	HIS119
Z	HIS12
Z	LYS41

---