Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042277 | molecular_function | peptide binding |
| A | 0043171 | biological_process | peptide catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0042277 | molecular_function | peptide binding |
| B | 0043171 | biological_process | peptide catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1001 |
| Chain | Residue |
| A | ARG708 |
| A | ARG711 |
| A | ARG711 |
| A | ARG715 |
| A | HOH2081 |
| A | HOH2261 |
| A | HOH2404 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1002 |
| Chain | Residue |
| A | HOH2342 |
| A | HOH2433 |
| A | LYS677 |
| A | THR718 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1003 |
| Chain | Residue |
| A | TYR409 |
| A | ARG444 |
| B | TYR172 |
| B | TYR174 |
| B | HOH2118 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1004 |
| Chain | Residue |
| B | ASP7 |
| B | THR22 |
| B | GLU23 |
| B | THR24 |
| B | GLU72 |
| B | HOH2018 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1005 |
| Chain | Residue |
| A | THR559 |
| A | HIS560 |
| A | HOH2143 |
| B | SER602 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1006 |
| Chain | Residue |
| A | TYR194 |
| A | LYS256 |
| A | ARG257 |
| A | PHE303 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1007 |
| Chain | Residue |
| A | PRO505 |
| A | ARG508 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1008 |
| Chain | Residue |
| A | PHE516 |
| A | GLY550 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1009 |
| Chain | Residue |
| A | LYS677 |
| A | LYS682 |
| A | PHE717 |
| A | HOH2102 |
| A | HOH2322 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1010 |
| Chain | Residue |
| A | GLU440 |
| A | SER521 |
| A | GLY522 |
| A | HIS523 |
| A | HOH2039 |
| A | HOH2120 |
| A | HOH2210 |
| B | LYS140 |
| B | ARG141 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1011 |
| Chain | Residue |
| A | TYR174 |
| B | TYR409 |
| B | ASN413 |
| B | PRO414 |
| B | ARG444 |
| B | TRP445 |
| B | HOH2031 |
| B | HOH2125 |
| B | HOH2207 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1012 |
| Chain | Residue |
| B | VAL112 |
| B | TYR117 |
| B | HOH2085 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1013 |
| Chain | Residue |
| A | SER602 |
| B | THR559 |
| B | HIS560 |
| B | ALA561 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1014 |
| Chain | Residue |
| A | LYS140 |
| A | ARG141 |
| A | GLU151 |
| A | SO41015 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1015 |
| Chain | Residue |
| A | LYS140 |
| A | SO41014 |
| B | HOH2308 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1016 |
| Chain | Residue |
| A | LYS580 |
| A | GLN581 |
| A | ASP582 |
| A | HOH2391 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1017 |
| Chain | Residue |
| A | ARG648 |
| A | ASP649 |
| A | GLU650 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 2001 |
| Chain | Residue |
| A | HIS265 |
| A | HIS269 |
| A | GLU288 |
| A | HOH2440 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 2002 |
| Chain | Residue |
| B | HIS265 |
| B | GLU266 |
| B | HIS269 |
| B | GLU288 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIAHEIAHQW |
| Chain | Residue | Details |
| A | VAL262-TRP271 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1h19 |
| Chain | Residue | Details |
| A | GLU266 | |
| A | TYR351 | |
| A | GLU233 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1h19 |
| Chain | Residue | Details |
| B | GLU266 | |
| B | TYR351 | |
| B | GLU233 | |
