1Z4R

Human GCN5 Acetyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	34
Details	BINDING SITE FOR RESIDUE ACO A 401

Chain	Residue
A	HIS502
A	PHE578
A	CYS579
A	ALA580
A	VAL581
A	GLN586
A	VAL587
A	LYS588
A	GLY589
A	TYR590
A	GLY591
A	ALA512
A	THR592
A	THR612
A	TYR613
A	ASP615
A	TYR617
A	GLY620
A	TYR621
A	LYS624
A	HOH1002
A	HOH1008
A	ASN513
A	HOH1013
A	HOH1024
A	HOH1033
A	HOH1036
A	HOH1044
A	ARG515
A	TRP519
A	GLN530
A	LEU531
A	ILE576
A	VAL577

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:31527837

Chain	Residue	Details
A	GLU575

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:29211711, ECO:0007744|PDB:5TRL

Chain	Residue	Details
A	CYS579
A	GLN586
A	TYR617

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:23142079

Chain	Residue	Details
A	LYS549

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ygh

Chain	Residue	Details
A	GLU575

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site_id	CSA2
Number of Residues	9
Details	Annotated By Reference To The Literature 1ygh

Chain	Residue	Details
A	ILE642
A	LEU611
A	TYR645
A	GLU575
A	CYS579
A	ILE576
A	VAL577
A	PHE568
A	PHE573

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site_id	MCSA1
Number of Residues	9
Details	M-CSA 524

Chain	Residue	Details
A	PHE568	electrostatic stabiliser
A	PHE573	electrostatic stabiliser
A	GLU575	proton acceptor
A	ILE576	electrostatic stabiliser
A	VAL577	electrostatic stabiliser
A	CYS579	electrostatic stabiliser
A	LEU611	electrostatic stabiliser
A	ILE642	electrostatic stabiliser
A	TYR645	electrostatic stabiliser

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