1Z2U

The 1.1A crystallographic structure of ubiquitin-conjugating enzyme (ubc-2) from Caenorhabditis elegans: functional and evolutionary significance

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010623	biological_process	programmed cell death involved in cell development
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0061631	molecular_function	ubiquitin conjugating enzyme activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 601

Chain	Residue
A	THR58
A	ASP59
A	LYS63
A	UNX502

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 602

Chain	Residue
A	SER-1
A	ARG131
A	LYS144
A	HOH318

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 603

Chain	Residue
A	LEU3
A	ARG131
A	HOH315
A	HOH356
A	HIS0

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 604

Chain	Residue
A	ARG15

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 605

Chain	Residue
A	GLY-2
A	HIS0
A	LYS4
A	MET147

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 606

Chain	Residue
A	BU3201
A	HOH317
A	HOH334

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 701

Chain	Residue
A	SER-1
A	ASP112
A	PRO113
A	TYR127
A	BU3201

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BU3 A 201

Chain	Residue
A	SER-1
A	ASP112
A	PRO113
A	PRO115
A	ASP116
A	HOH319
A	HOH353
A	CL606
A	NA701

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BU3 A 202

Chain	Residue
A	ARG15
A	HOH383
A	HOH404

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE UNX A 501

Chain	Residue
A	ASP28
A	ASP29
A	LEU30
A	PHE31
A	ARG139

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX A 502

Chain	Residue
A	CL601

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX A 503

Chain	Residue
A	ASP130

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 504

Chain	Residue
A	SER22
A	THR36

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UNX A 505

Chain	Residue
A	LEU86
A	ASN114
A	HOH364

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE UNX A 506

Chain	Residue
A	VAL26
A	ASP29
A	SER94
A	ARG139
A	UNX508
A	UNX509

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UNX A 507

Chain	Residue
A	GLN34
A	ALA35
A	THR36

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE UNX A 508

Chain	Residue
A	GLY27
A	ASP28
A	ALA96
A	ARG139
A	UNX506

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE UNX A 509

Chain	Residue
A	HIS32
A	SER94
A	UNX506
A	UNX510

---

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 510

Chain	Residue
A	GLN136
A	UNX509

---

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNInsn.GsICLdiL

Chain	Residue	Details
A	TYR74-LEU89

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	146
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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