Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1Z2C

Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000281	biological_process	mitotic cytokinesis
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007015	biological_process	actin filament organization
A	0007165	biological_process	signal transduction
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0019901	molecular_function	protein kinase binding
A	0030335	biological_process	positive regulation of cell migration
A	0031334	biological_process	positive regulation of protein-containing complex assembly
A	0032154	cellular_component	cleavage furrow
A	0032420	cellular_component	stereocilium
A	0032956	biological_process	regulation of actin cytoskeleton organization
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043297	biological_process	apical junction assembly
A	0044319	biological_process	wound healing, spreading of cells
A	0051496	biological_process	positive regulation of stress fiber assembly
A	0060193	biological_process	positive regulation of lipase activity
A	0070062	cellular_component	extracellular exosome
A	1902766	biological_process	skeletal muscle satellite cell migration
B	0003779	molecular_function	actin binding
B	0016043	biological_process	cellular component organization
B	0030036	biological_process	actin cytoskeleton organization
B	0031267	molecular_function	small GTPase binding
C	0000281	biological_process	mitotic cytokinesis
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0007015	biological_process	actin filament organization
C	0007165	biological_process	signal transduction
C	0007264	biological_process	small GTPase-mediated signal transduction
C	0019901	molecular_function	protein kinase binding
C	0030335	biological_process	positive regulation of cell migration
C	0031334	biological_process	positive regulation of protein-containing complex assembly
C	0032154	cellular_component	cleavage furrow
C	0032420	cellular_component	stereocilium
C	0032956	biological_process	regulation of actin cytoskeleton organization
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043297	biological_process	apical junction assembly
C	0044319	biological_process	wound healing, spreading of cells
C	0051496	biological_process	positive regulation of stress fiber assembly
C	0060193	biological_process	positive regulation of lipase activity
C	0070062	cellular_component	extracellular exosome
C	1902766	biological_process	skeletal muscle satellite cell migration
D	0003779	molecular_function	actin binding
D	0016043	biological_process	cellular component organization
D	0030036	biological_process	actin cytoskeleton organization
D	0031267	molecular_function	small GTPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 194

Chain	Residue
A	THR19
A	THR37
A	GNP195

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 194

Chain	Residue
C	THR19
C	THR37
C	GNP195

site_id	AC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GNP A 195

Chain	Residue
A	GLY17
A	LYS18
A	THR19
A	CYS20
A	PHE30
A	PRO31
A	TYR34
A	PRO36
A	THR37
A	THR60
A	GLY62
A	LYS118
A	ASP120
A	LEU121
A	SER160
A	ALA161
A	LYS162
A	MG194
A	GLY14
A	ALA15
A	CYS16

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GNP C 195

Chain	Residue
C	GLY14
C	ALA15
C	CYS16
C	GLY17
C	LYS18
C	THR19
C	CYS20
C	PHE30
C	TYR34
C	PRO36
C	THR37
C	GLY62
C	LYS118
C	ASP120
C	LEU121
C	SER160
C	ALA161
C	LYS162
C	MG194

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLY12
A	ASP59
A	ASN117
C	GLY12
C	ASP59
C	ASN117

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: ADP-ribosylasparagine; by botulinum toxin => ECO:0000250

Chain	Residue	Details
A	ASN41
C	ASN41

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Cysteine methyl ester => ECO:0000250\|UniProtKB:P62745

Chain	Residue	Details
A	CYS190
C	CYS190

site_id	SWS_FT_FI4
Number of Residues	2
Details	LIPID: S-geranylgeranyl cysteine => ECO:0000250\|UniProtKB:P62745

Chain	Residue	Details
A	CYS190
C	CYS190

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230 => ECO:0000269\|PubMed:24141704

Chain	Residue	Details
A	TYR34
C	TYR34

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB => ECO:0000269\|PubMed:24905543

Chain	Residue	Details
A	THR37
C	THR37

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)