1Z2C

Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000281	biological_process	mitotic cytokinesis
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007015	biological_process	actin filament organization
A	0007165	biological_process	signal transduction
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0016020	cellular_component	membrane
A	0016477	biological_process	cell migration
A	0019901	molecular_function	protein kinase binding
A	0030335	biological_process	positive regulation of cell migration
A	0031334	biological_process	positive regulation of protein-containing complex assembly
A	0032154	cellular_component	cleavage furrow
A	0032420	cellular_component	stereocilium
A	0032956	biological_process	regulation of actin cytoskeleton organization
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043297	biological_process	apical junction assembly
A	0044319	biological_process	wound healing, spreading of cells
A	0051496	biological_process	positive regulation of stress fiber assembly
A	0060193	biological_process	positive regulation of lipase activity
A	0070062	cellular_component	extracellular exosome
A	1902766	biological_process	skeletal muscle satellite cell migration
B	0003779	molecular_function	actin binding
B	0016043	biological_process	cellular component organization
B	0030036	biological_process	actin cytoskeleton organization
B	0031267	molecular_function	small GTPase binding
C	0000166	molecular_function	nucleotide binding
C	0000281	biological_process	mitotic cytokinesis
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0007015	biological_process	actin filament organization
C	0007165	biological_process	signal transduction
C	0007264	biological_process	small GTPase-mediated signal transduction
C	0016020	cellular_component	membrane
C	0016477	biological_process	cell migration
C	0019901	molecular_function	protein kinase binding
C	0030335	biological_process	positive regulation of cell migration
C	0031334	biological_process	positive regulation of protein-containing complex assembly
C	0032154	cellular_component	cleavage furrow
C	0032420	cellular_component	stereocilium
C	0032956	biological_process	regulation of actin cytoskeleton organization
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043297	biological_process	apical junction assembly
C	0044319	biological_process	wound healing, spreading of cells
C	0051496	biological_process	positive regulation of stress fiber assembly
C	0060193	biological_process	positive regulation of lipase activity
C	0070062	cellular_component	extracellular exosome
C	1902766	biological_process	skeletal muscle satellite cell migration
D	0003779	molecular_function	actin binding
D	0016043	biological_process	cellular component organization
D	0030036	biological_process	actin cytoskeleton organization
D	0031267	molecular_function	small GTPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 194

Chain	Residue
A	THR19
A	THR37
A	GNP195

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 194

Chain	Residue
C	THR19
C	THR37
C	GNP195

---

site_id	AC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GNP A 195

Chain	Residue
A	GLY17
A	LYS18
A	THR19
A	CYS20
A	PHE30
A	PRO31
A	TYR34
A	PRO36
A	THR37
A	THR60
A	GLY62
A	LYS118
A	ASP120
A	LEU121
A	SER160
A	ALA161
A	LYS162
A	MG194
A	GLY14
A	ALA15
A	CYS16

---

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GNP C 195

Chain	Residue
C	GLY14
C	ALA15
C	CYS16
C	GLY17
C	LYS18
C	THR19
C	CYS20
C	PHE30
C	TYR34
C	PRO36
C	THR37
C	GLY62
C	LYS118
C	ASP120
C	LEU121
C	SER160
C	ALA161
C	LYS162
C	MG194

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"ADP-ribosylasparagine; by botulinum toxin","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN63

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	GLN63

---