Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1Z08

GppNHp-Bound Rab21 Q53G mutant GTPase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0032482	biological_process	Rab protein signal transduction
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0032482	biological_process	Rab protein signal transduction
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0032482	biological_process	Rab protein signal transduction
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0032482	biological_process	Rab protein signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1300

Chain	Residue
A	THR33
A	THR51
A	GNP1200
A	HOH1307
A	HOH1315

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 2300

Chain	Residue
B	HOH2309
B	THR33
B	THR51
B	GNP2200
B	HOH2308

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 3300

Chain	Residue
C	THR33
C	GNP3200
C	HOH5007
C	HOH5009
C	HOH5014

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 4300

Chain	Residue
D	THR33
D	GNP4200
D	HOH5011
D	HOH5022
D	HOH5032

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 5001

Chain	Residue
D	MET180
D	THR183
D	HOH5061
D	HOH5093
D	HOH5104
D	HOH5110

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 5002

Chain	Residue
D	GLU79
D	HOH5063
D	HOH5064
D	HOH5103
D	HOH5128
D	HOH5214

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 5003

Chain	Residue
C	HOH5042
C	HOH5071
C	HOH5078
D	HOH5042
D	HOH5045
D	HOH5068

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 5004

Chain	Residue
C	GLU79
C	HOH5041
C	HOH5052
C	HOH5070
C	HOH5109
C	HOH5185

site_id	AC9
Number of Residues	30
Details	BINDING SITE FOR RESIDUE GNP A 1200

Chain	Residue
A	GLY28
A	CYS29
A	GLY31
A	LYS32
A	THR33
A	SER34
A	PHE44
A	ASN45
A	ASP46
A	HIS48
A	THR51
A	GLY77
A	ASN132
A	LYS133
A	ASP135
A	LEU136
A	SER162
A	ALA163
A	LYS164
A	MG1300
A	HOH1307
A	HOH1315
A	HOH1317
A	HOH1319
A	HOH1324
A	HOH1329
A	HOH1362
A	HOH1442
A	HOH1496
A	HOH1517

site_id	BC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE GNP B 2200

Chain	Residue
B	HOH2319
B	HOH2321
B	HOH2338
B	HOH2384
B	HOH2397
B	HOH2469
B	GLU27
B	GLY28
B	CYS29
B	GLY31
B	LYS32
B	THR33
B	SER34
B	PHE44
B	ASN45
B	ASP46
B	HIS48
B	THR50
B	THR51
B	GLY77
B	ASN132
B	LYS133
B	ASP135
B	LEU136
B	SER162
B	ALA163
B	LYS164
B	MG2300
B	HOH2308
B	HOH2309
B	HOH2316

site_id	BC2
Number of Residues	31
Details	BINDING SITE FOR RESIDUE GNP C 3200

Chain	Residue
C	GLY28
C	GLY31
C	LYS32
C	THR33
C	SER34
C	PHE44
C	ASN45
C	ASP46
C	HIS48
C	ALA76
C	GLY77
C	ASN132
C	LYS133
C	ASP135
C	LEU136
C	SER162
C	ALA163
C	LYS164
C	MG3300
C	HOH5007
C	HOH5009
C	HOH5014
C	HOH5017
C	HOH5021
C	HOH5023
C	HOH5041
C	HOH5051
C	HOH5070
C	HOH5106
C	HOH5169
C	HOH5302

site_id	BC3
Number of Residues	31
Details	BINDING SITE FOR RESIDUE GNP D 4200

Chain	Residue
D	GLY28
D	CYS29
D	GLY31
D	LYS32
D	THR33
D	SER34
D	PHE44
D	ASN45
D	ASP46
D	HIS48
D	ALA76
D	GLY77
D	ASN132
D	LYS133
D	ASP135
D	LEU136
D	SER162
D	ALA163
D	LYS164
D	MG4300
D	HOH5011
D	HOH5015
D	HOH5022
D	HOH5032
D	HOH5034
D	HOH5052
D	HOH5063
D	HOH5095
D	HOH5100
D	HOH5103
D	HOH5109

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	52
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Z08","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Z0I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	44
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1YZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Z08","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Z08","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Z0I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1YZT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Z08","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Z0I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1Z08","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1YZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	36
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Z08","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Z0I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN78

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLN78

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	GLN78

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
D	GLN78

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)