1YZX
Crystal structure of human kappa class glutathione transferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004602 | molecular_function | glutathione peroxidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005782 | cellular_component | peroxisomal matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030855 | biological_process | epithelial cell differentiation |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0004602 | molecular_function | glutathione peroxidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005777 | cellular_component | peroxisome |
| B | 0005782 | cellular_component | peroxisomal matrix |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030855 | biological_process | epithelial cell differentiation |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GSF A 301 |
| Chain | Residue |
| A | SER16 |
| A | GLY199 |
| A | SER200 |
| A | ASP201 |
| A | HOH401 |
| A | HOH402 |
| A | HOH495 |
| A | HOH522 |
| B | LYS62 |
| B | ARG202 |
| A | PRO17 |
| A | TYR18 |
| A | ILE44 |
| A | MET48 |
| A | ASN53 |
| A | GLY182 |
| A | LEU183 |
| A | PHE198 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE GSF B 1301 |
| Chain | Residue |
| A | LYS62 |
| A | ARG202 |
| B | SER16 |
| B | PRO17 |
| B | TYR18 |
| B | ILE44 |
| B | MET48 |
| B | ASN53 |
| B | MET91 |
| B | GLY182 |
| B | LEU183 |
| B | PHE198 |
| B | GLY199 |
| B | SER200 |
| B | ASP201 |
| B | HOH447 |
| B | HOH456 |
| B | HOH494 |
| B | HOH517 |
| B | HOH562 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16081649 |
| Chain | Residue | Details |
| A | PRO17 | |
| A | LYS54 | |
| A | PRO184 | |
| A | ASP201 | |
| B | PRO17 | |
| B | LYS54 | |
| B | PRO184 | |
| B | ASP201 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9DCM2 |
| Chain | Residue | Details |
| A | ASP50 | |
| A | ALA145 | |
| B | ASP50 | |
| B | ALA145 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LEU72 | |
| A | GLU170 | |
| B | LEU72 | |
| B | GLU170 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9DCM2 |
| Chain | Residue | Details |
| A | ASP86 | |
| A | ASN166 | |
| B | ASP86 | |
| B | ASN166 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9DCM2 |
| Chain | Residue | Details |
| A | ALA117 | |
| A | ILE159 | |
| B | ALA117 | |
| B | ILE159 |
