1YZX
Crystal structure of human kappa class glutathione transferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001889 | biological_process | liver development |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004602 | molecular_function | glutathione peroxidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005782 | cellular_component | peroxisomal matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0010042 | biological_process | response to manganese ion |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030855 | biological_process | epithelial cell differentiation |
| A | 0046685 | biological_process | response to arsenic-containing substance |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0001889 | biological_process | liver development |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0004602 | molecular_function | glutathione peroxidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005777 | cellular_component | peroxisome |
| B | 0005782 | cellular_component | peroxisomal matrix |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0010042 | biological_process | response to manganese ion |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030855 | biological_process | epithelial cell differentiation |
| B | 0046685 | biological_process | response to arsenic-containing substance |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GSF A 301 |
| Chain | Residue |
| A | SER16 |
| A | GLY199 |
| A | SER200 |
| A | ASP201 |
| A | HOH401 |
| A | HOH402 |
| A | HOH495 |
| A | HOH522 |
| B | LYS62 |
| B | ARG202 |
| A | PRO17 |
| A | TYR18 |
| A | ILE44 |
| A | MET48 |
| A | ASN53 |
| A | GLY182 |
| A | LEU183 |
| A | PHE198 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE GSF B 1301 |
| Chain | Residue |
| A | LYS62 |
| A | ARG202 |
| B | SER16 |
| B | PRO17 |
| B | TYR18 |
| B | ILE44 |
| B | MET48 |
| B | ASN53 |
| B | MET91 |
| B | GLY182 |
| B | LEU183 |
| B | PHE198 |
| B | GLY199 |
| B | SER200 |
| B | ASP201 |
| B | HOH447 |
| B | HOH456 |
| B | HOH494 |
| B | HOH517 |
| B | HOH562 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16081649","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9DCM2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DCM2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9DCM2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
