1YYW

Crystal structure of RNase III from Aquifex aeolicus complexed with double stranded RNA at 2.8-Angstrom Resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003725	molecular_function	double-stranded RNA binding
A	0004519	molecular_function	endonuclease activity
A	0004525	molecular_function	ribonuclease III activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006364	biological_process	rRNA processing
A	0006396	biological_process	RNA processing
A	0006397	biological_process	mRNA processing
A	0008033	biological_process	tRNA processing
A	0010468	biological_process	regulation of gene expression
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
B	0003723	molecular_function	RNA binding
B	0003725	molecular_function	double-stranded RNA binding
B	0004519	molecular_function	endonuclease activity
B	0004525	molecular_function	ribonuclease III activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006364	biological_process	rRNA processing
B	0006396	biological_process	RNA processing
B	0006397	biological_process	mRNA processing
B	0008033	biological_process	tRNA processing
B	0010468	biological_process	regulation of gene expression
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
C	0003723	molecular_function	RNA binding
C	0003725	molecular_function	double-stranded RNA binding
C	0004519	molecular_function	endonuclease activity
C	0004525	molecular_function	ribonuclease III activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006364	biological_process	rRNA processing
C	0006396	biological_process	RNA processing
C	0006397	biological_process	mRNA processing
C	0008033	biological_process	tRNA processing
C	0010468	biological_process	regulation of gene expression
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
D	0003723	molecular_function	RNA binding
D	0003725	molecular_function	double-stranded RNA binding
D	0004519	molecular_function	endonuclease activity
D	0004525	molecular_function	ribonuclease III activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006364	biological_process	rRNA processing
D	0006396	biological_process	RNA processing
D	0006397	biological_process	mRNA processing
D	0008033	biological_process	tRNA processing
D	0010468	biological_process	regulation of gene expression
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00517
Number of Residues	9
Details	RNASE_3_1 Ribonuclease III family signature. ETLEFLGDA

Chain	Residue	Details
A	GLU37-ALA45

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000255

Chain	Residue	Details
A	ASP44
B	ASP44
C	ASP44
D	ASP44

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000305

Chain	Residue	Details
A	GLU110
B	GLU110
C	GLU110
D	GLU110

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site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:15016361, ECO:0000269|PubMed:18047582, ECO:0000305|PubMed:11738048, ECO:0007744|PDB:1JFZ, ECO:0007744|PDB:1RC5

Chain	Residue	Details
A	GLU40
D	GLU40
D	ASP107
D	GLU110
A	ASP107
A	GLU110
B	GLU40
B	ASP107
B	GLU110
C	GLU40
C	ASP107
C	GLU110

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