1YWG

The structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum

Functional Information from GO Data

Chain	GOid	namespace	contents
O	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006006	biological_process	glucose metabolic process
O	0006096	biological_process	glycolytic process
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0050661	molecular_function	NADP binding
O	0051287	molecular_function	NAD binding
P	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006006	biological_process	glucose metabolic process
P	0006096	biological_process	glycolytic process
P	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
P	0050661	molecular_function	NADP binding
P	0051287	molecular_function	NAD binding
Q	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006006	biological_process	glucose metabolic process
Q	0006096	biological_process	glycolytic process
Q	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Q	0050661	molecular_function	NADP binding
Q	0051287	molecular_function	NAD binding
R	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006006	biological_process	glucose metabolic process
R	0006096	biological_process	glycolytic process
R	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
R	0050661	molecular_function	NADP binding
R	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE NAD O 401

Chain	Residue
O	ASN9
O	PHE37
O	GLU79
O	LYS80
O	SER98
O	THR99
O	PHE102
O	SER122
O	ALA123
O	CYS153
O	THR183
O	GLY10
O	ALA184
O	ASN319
O	TYR323
O	HOH406
O	HOH415
O	HOH469
O	HOH541
O	HOH544
O	HOH586
O	HOH639
O	PHE11
O	HOH659
O	HOH700
O	GLY12
O	ARG13
O	ILE14
O	ASN34
O	ASP35
O	PRO36

---

site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD P 402

Chain	Residue
P	ASN9
P	GLY10
P	PHE11
P	GLY12
P	ARG13
P	ILE14
P	ASN34
P	ASP35
P	PRO36
P	PHE37
P	GLU79
P	LYS80
P	SER98
P	THR99
P	PHE102
P	SER122
P	ALA123
P	CYS153
P	ALA184
P	ASN319
P	TYR323
P	HOH492
P	HOH493
P	HOH563
P	HOH665
P	HOH711

---

site_id	AC3
Number of Residues	28
Details	BINDING SITE FOR RESIDUE NAD Q 403

Chain	Residue
P	HOH655
Q	ASN9
Q	GLY10
Q	PHE11
Q	GLY12
Q	ARG13
Q	ILE14
Q	ASN34
Q	ASP35
Q	PRO36
Q	PHE37
Q	GLU79
Q	LYS80
Q	SER98
Q	THR99
Q	PHE102
Q	SER122
Q	ALA123
Q	CYS153
Q	ALA184
Q	ASN319
Q	TYR323
Q	HOH429
Q	HOH436
Q	HOH498
Q	HOH511
Q	HOH716
Q	HOH831

---

site_id	AC4
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD R 404

Chain	Residue
R	PHE102
R	SER122
R	ALA123
R	CYS153
R	ALA184
R	ASN319
R	TYR323
R	HOH442
R	HOH471
R	HOH577
R	HOH734
R	HOH736
R	HOH789
R	ASN9
R	GLY10
R	PHE11
R	GLY12
R	ARG13
R	ILE14
R	ASN34
R	ASP35
R	PRO36
R	PHE37
R	GLU79
R	LYS80
R	SER98
R	THR99

---

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
O	ALA151-LEU158

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FPCEVTH

Chain	Residue	Details
O	PHE56-HIS62

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
O	HIS180
O	CYS153

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
P	HIS180
P	CYS153

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
Q	HIS180
Q	CYS153

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
R	HIS180
R	CYS153

---