1YVL

Structure of Unphosphorylated STAT1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000785	cellular_component	chromatin
A	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
A	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
A	0001222	molecular_function	transcription corepressor binding
A	0001223	molecular_function	transcription coactivator binding
A	0001937	biological_process	negative regulation of endothelial cell proliferation
A	0002053	biological_process	positive regulation of mesenchymal cell proliferation
A	0002230	biological_process	positive regulation of defense response to virus by host
A	0003340	biological_process	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
A	0003677	molecular_function	DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006952	biological_process	defense response
A	0007165	biological_process	signal transduction
A	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
A	0016525	biological_process	negative regulation of angiogenesis
A	0019899	molecular_function	enzyme binding
A	0032727	biological_process	positive regulation of interferon-alpha production
A	0032991	cellular_component	protein-containing complex
A	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
A	0034341	biological_process	response to type II interferon
A	0035035	molecular_function	histone acetyltransferase binding
A	0035456	biological_process	response to interferon-beta
A	0035458	biological_process	cellular response to interferon-beta
A	0038111	biological_process	interleukin-7-mediated signaling pathway
A	0038113	biological_process	interleukin-9-mediated signaling pathway
A	0042127	biological_process	regulation of cell population proliferation
A	0042393	molecular_function	histone binding
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042981	biological_process	regulation of apoptotic process
A	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
A	0043434	biological_process	response to peptide hormone
A	0043542	biological_process	endothelial cell migration
A	0044389	molecular_function	ubiquitin-like protein ligase binding
A	0045296	molecular_function	cadherin binding
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046725	biological_process	negative regulation by virus of viral protein levels in host cell
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051093	biological_process	negative regulation of developmental process
A	0051607	biological_process	defense response to virus
A	0060333	biological_process	type II interferon-mediated signaling pathway
A	0060337	biological_process	type I interferon-mediated signaling pathway
A	0061326	biological_process	renal tubule development
A	0070106	biological_process	interleukin-27-mediated signaling pathway
A	0070721	cellular_component	ISGF3 complex
A	0071346	biological_process	cellular response to type II interferon
A	0072136	biological_process	metanephric mesenchymal cell proliferation involved in metanephros development
A	0072162	biological_process	metanephric mesenchymal cell differentiation
A	0072308	biological_process	negative regulation of metanephric nephron tubule epithelial cell differentiation
A	0090575	cellular_component	RNA polymerase II transcription regulator complex
A	0097696	biological_process	cell surface receptor signaling pathway via STAT
A	1990841	molecular_function	promoter-specific chromatin binding
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000785	cellular_component	chromatin
B	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
B	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
B	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
B	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
B	0001222	molecular_function	transcription corepressor binding
B	0001223	molecular_function	transcription coactivator binding
B	0001937	biological_process	negative regulation of endothelial cell proliferation
B	0002053	biological_process	positive regulation of mesenchymal cell proliferation
B	0002230	biological_process	positive regulation of defense response to virus by host
B	0003340	biological_process	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
B	0003677	molecular_function	DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005164	molecular_function	tumor necrosis factor receptor binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006952	biological_process	defense response
B	0007165	biological_process	signal transduction
B	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
B	0016525	biological_process	negative regulation of angiogenesis
B	0019899	molecular_function	enzyme binding
B	0032727	biological_process	positive regulation of interferon-alpha production
B	0032991	cellular_component	protein-containing complex
B	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
B	0034341	biological_process	response to type II interferon
B	0035035	molecular_function	histone acetyltransferase binding
B	0035456	biological_process	response to interferon-beta
B	0035458	biological_process	cellular response to interferon-beta
B	0038111	biological_process	interleukin-7-mediated signaling pathway
B	0038113	biological_process	interleukin-9-mediated signaling pathway
B	0042127	biological_process	regulation of cell population proliferation
B	0042393	molecular_function	histone binding
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042981	biological_process	regulation of apoptotic process
B	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
B	0043434	biological_process	response to peptide hormone
B	0043542	biological_process	endothelial cell migration
B	0044389	molecular_function	ubiquitin-like protein ligase binding
B	0045296	molecular_function	cadherin binding
B	0045648	biological_process	positive regulation of erythrocyte differentiation
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046725	biological_process	negative regulation by virus of viral protein levels in host cell
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051093	biological_process	negative regulation of developmental process
B	0051607	biological_process	defense response to virus
B	0060333	biological_process	type II interferon-mediated signaling pathway
B	0060337	biological_process	type I interferon-mediated signaling pathway
B	0061326	biological_process	renal tubule development
B	0070106	biological_process	interleukin-27-mediated signaling pathway
B	0070721	cellular_component	ISGF3 complex
B	0071346	biological_process	cellular response to type II interferon
B	0072136	biological_process	metanephric mesenchymal cell proliferation involved in metanephros development
B	0072162	biological_process	metanephric mesenchymal cell differentiation
B	0072308	biological_process	negative regulation of metanephric nephron tubule epithelial cell differentiation
B	0090575	cellular_component	RNA polymerase II transcription regulator complex
B	0097696	biological_process	cell surface receptor signaling pathway via STAT
B	1990841	molecular_function	promoter-specific chromatin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE AU A 2001

Chain	Residue
A	CYS247
A	PRO332

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE AU B 2002

Chain	Residue
B	CYS1247
B	PRO1332

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	14
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"28753426","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"ADP-ribosyl glutamic acid; by PARP14","evidences":[{"source":"PubMed","id":"27796300","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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