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1YVL

Structure of Unphosphorylated STAT1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000785cellular_componentchromatin
A0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
A0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
A0001222molecular_functiontranscription corepressor binding
A0001223molecular_functiontranscription coactivator binding
A0001937biological_processnegative regulation of endothelial cell proliferation
A0002053biological_processpositive regulation of mesenchymal cell proliferation
A0002230biological_processpositive regulation of defense response to virus by host
A0003340biological_processnegative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
A0003677molecular_functionDNA binding
A0003690molecular_functiondouble-stranded DNA binding
A0003700molecular_functionDNA-binding transcription factor activity
A0005164molecular_functiontumor necrosis factor receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0006952biological_processdefense response
A0007165biological_processsignal transduction
A0007166biological_processcell surface receptor signaling pathway
A0007259biological_processreceptor signaling pathway via JAK-STAT
A0007584biological_processresponse to nutrient
A0008015biological_processblood circulation
A0008284biological_processpositive regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0009612biological_processresponse to mechanical stimulus
A0010742biological_processmacrophage derived foam cell differentiation
A0014070biological_processresponse to organic cyclic compound
A0016525biological_processnegative regulation of angiogenesis
A0016922molecular_functionnuclear receptor binding
A0019899molecular_functionenzyme binding
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031730molecular_functionCCR5 chemokine receptor binding
A0032727biological_processpositive regulation of interferon-alpha production
A0032869biological_processcellular response to insulin stimulus
A0032991cellular_componentprotein-containing complex
A0033209biological_processtumor necrosis factor-mediated signaling pathway
A0034097biological_processresponse to cytokine
A0034341biological_processresponse to type II interferon
A0035035molecular_functionhistone acetyltransferase binding
A0035456biological_processresponse to interferon-beta
A0035458biological_processcellular response to interferon-beta
A0038113biological_processinterleukin-9-mediated signaling pathway
A0042127biological_processregulation of cell population proliferation
A0042393molecular_functionhistone binding
A0042542biological_processresponse to hydrogen peroxide
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042981biological_processregulation of apoptotic process
A0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
A0043434biological_processresponse to peptide hormone
A0043542biological_processendothelial cell migration
A0043565molecular_functionsequence-specific DNA binding
A0044389molecular_functionubiquitin-like protein ligase binding
A0045296molecular_functioncadherin binding
A0045648biological_processpositive regulation of erythrocyte differentiation
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046725biological_processnegative regulation by virus of viral protein levels in host cell
A0048471cellular_componentperinuclear region of cytoplasm
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0051591biological_processresponse to cAMP
A0051607biological_processdefense response to virus
A0051721molecular_functionprotein phosphatase 2A binding
A0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
A0060333biological_processtype II interferon-mediated signaling pathway
A0060337biological_processtype I interferon-mediated signaling pathway
A0061326biological_processrenal tubule development
A0070106biological_processinterleukin-27-mediated signaling pathway
A0070721cellular_componentISGF3 complex
A0071310biological_processcellular response to organic substance
A0071345biological_processcellular response to cytokine stimulus
A0071346biological_processcellular response to type II interferon
A0071407biological_processcellular response to organic cyclic compound
A0072136biological_processmetanephric mesenchymal cell proliferation involved in metanephros development
A0072162biological_processmetanephric mesenchymal cell differentiation
A0072308biological_processnegative regulation of metanephric nephron tubule epithelial cell differentiation
A0090575cellular_componentRNA polymerase II transcription regulator complex
A1990841molecular_functionpromoter-specific chromatin binding
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000785cellular_componentchromatin
B0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
B0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
B0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
B0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
B0001222molecular_functiontranscription corepressor binding
B0001223molecular_functiontranscription coactivator binding
B0001937biological_processnegative regulation of endothelial cell proliferation
B0002053biological_processpositive regulation of mesenchymal cell proliferation
B0002230biological_processpositive regulation of defense response to virus by host
B0003340biological_processnegative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
B0003677molecular_functionDNA binding
B0003690molecular_functiondouble-stranded DNA binding
B0003700molecular_functionDNA-binding transcription factor activity
B0005164molecular_functiontumor necrosis factor receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006355biological_processregulation of DNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0006952biological_processdefense response
B0007165biological_processsignal transduction
B0007166biological_processcell surface receptor signaling pathway
B0007259biological_processreceptor signaling pathway via JAK-STAT
B0007584biological_processresponse to nutrient
B0008015biological_processblood circulation
B0008284biological_processpositive regulation of cell population proliferation
B0009410biological_processresponse to xenobiotic stimulus
B0009612biological_processresponse to mechanical stimulus
B0010742biological_processmacrophage derived foam cell differentiation
B0014070biological_processresponse to organic cyclic compound
B0016525biological_processnegative regulation of angiogenesis
B0016922molecular_functionnuclear receptor binding
B0019899molecular_functionenzyme binding
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0031730molecular_functionCCR5 chemokine receptor binding
B0032727biological_processpositive regulation of interferon-alpha production
B0032869biological_processcellular response to insulin stimulus
B0032991cellular_componentprotein-containing complex
B0033209biological_processtumor necrosis factor-mediated signaling pathway
B0034097biological_processresponse to cytokine
B0034341biological_processresponse to type II interferon
B0035035molecular_functionhistone acetyltransferase binding
B0035456biological_processresponse to interferon-beta
B0035458biological_processcellular response to interferon-beta
B0038113biological_processinterleukin-9-mediated signaling pathway
B0042127biological_processregulation of cell population proliferation
B0042393molecular_functionhistone binding
B0042542biological_processresponse to hydrogen peroxide
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042981biological_processregulation of apoptotic process
B0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
B0043434biological_processresponse to peptide hormone
B0043542biological_processendothelial cell migration
B0043565molecular_functionsequence-specific DNA binding
B0044389molecular_functionubiquitin-like protein ligase binding
B0045296molecular_functioncadherin binding
B0045648biological_processpositive regulation of erythrocyte differentiation
B0045893biological_processpositive regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046725biological_processnegative regulation by virus of viral protein levels in host cell
B0048471cellular_componentperinuclear region of cytoplasm
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0051591biological_processresponse to cAMP
B0051607biological_processdefense response to virus
B0051721molecular_functionprotein phosphatase 2A binding
B0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
B0060333biological_processtype II interferon-mediated signaling pathway
B0060337biological_processtype I interferon-mediated signaling pathway
B0061326biological_processrenal tubule development
B0070106biological_processinterleukin-27-mediated signaling pathway
B0070721cellular_componentISGF3 complex
B0071310biological_processcellular response to organic substance
B0071345biological_processcellular response to cytokine stimulus
B0071346biological_processcellular response to type II interferon
B0071407biological_processcellular response to organic cyclic compound
B0072136biological_processmetanephric mesenchymal cell proliferation involved in metanephros development
B0072162biological_processmetanephric mesenchymal cell differentiation
B0072308biological_processnegative regulation of metanephric nephron tubule epithelial cell differentiation
B0090575cellular_componentRNA polymerase II transcription regulator complex
B1990841molecular_functionpromoter-specific chromatin binding
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE AU A 2001
ChainResidue
ACYS247
APRO332

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE AU B 2002
ChainResidue
BCYS1247
BPRO1332

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:22223895
ChainResidueDetails
ASER2
BSER1002

site_idSWS_FT_FI2
Number of Residues14
DetailsMOD_RES: N6-methyllysine => ECO:0000269|PubMed:28753426
ChainResidueDetails
ALYS114
BLYS1296
BLYS1366
BLYS1525
BLYS1637
BLYS1665
ALYS175
ALYS296
ALYS366
ALYS525
ALYS637
ALYS665
BLYS1114
BLYS1175

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: ADP-ribosyl glutamic acid; by PARP14 => ECO:0000269|PubMed:27796300
ChainResidueDetails
AGLU657
BGLU1657

217705

PDB entries from 2024-03-27

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