1YUC

Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to Phospholipid and a Fragment of Human SHP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
B	0003677	molecular_function	DNA binding
B	0004879	molecular_function	nuclear receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 5001

Chain	Residue
A	GLU494
A	GLY497
B	HOH41

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 5002

Chain	Residue
A	GLN498
A	ARG502
B	HOH212
B	LEU482
B	ASP483

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 5003

Chain	Residue
B	HOH8
B	HOH34
B	GLU384
B	SER458
B	ASP460
B	LEU503
A	HOH142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15897460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22187462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22504882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26416531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26553876","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RWV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	239
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	Region: {"description":"AF-2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---