Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1 |
| Chain | Residue |
| A | ASP356 |
| A | SER403 |
| A | ARG404 |
| A | ALA405 |
| A | GLY406 |
| A | VAL407 |
| A | GLY408 |
| A | ARG409 |
| A | HOH522 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2 |
| Chain | Residue |
| A | ARG278 |
| A | SER388 |
| A | SER389 |
| A | ALA390 |
| site_id | PL |
| Number of Residues | 9 |
| Details | THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES |
| Chain | Residue |
| A | HIS402 |
| A | SER403 |
| A | ARG404 |
| A | ALA405 |
| A | GLY406 |
| A | VAL407 |
| A | GLY408 |
| A | ARG409 |
| A | THR410 |
| site_id | WPD |
| Number of Residues | 11 |
| Details | THE FLEXIBLE LOOP CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE SULFATE ANION IN THE SULFATE-BOUND STRUCTURE. |
| Chain | Residue |
| A | HIS350 |
| A | VAL351 |
| A | GLY352 |
| A | ASN353 |
| A | TRP354 |
| A | PRO355 |
| A | ASP356 |
| A | GLN357 |
| A | THR358 |
| A | ALA359 |
| A | VAL360 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Phosphocysteine intermediate |
| Chain | Residue | Details |
| A | SER403 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | ASP356 | |
| A | THR410 | |
| A | SER403 | |
| A | ARG409 | |
| A | GLU290 | |
| A | HIS402 | |
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 47 |
| Chain | Residue | Details |
| A | GLU290 | steric role |
| A | TRP354 | steric role |
| A | ASP356 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | HIS402 | electrostatic stabiliser, hydrogen bond donor |
| A | SER403 | nucleofuge, nucleophile |
| A | ARG409 | electrostatic stabiliser, hydrogen bond donor |
| A | THR410 | electrostatic stabiliser, hydrogen bond donor |
