1YTK
Crystal structure of a nicotinate phosphoribosyltransferase from Thermoplasma acidophilum with nicotinate mononucleotide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| A | 0004516 | molecular_function | nicotinate phosphoribosyltransferase activity |
| A | 0009435 | biological_process | NAD+ biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0016874 | molecular_function | ligase activity |
| A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NCN A 401 |
| Chain | Residue |
| A | ASP19 |
| A | ASP237 |
| A | GLY272 |
| A | GLY292 |
| A | THR293 |
| A | HOH503 |
| A | HOH518 |
| A | HOH536 |
| A | TYR21 |
| A | PHE138 |
| A | ARG141 |
| A | ARG142 |
| A | SER164 |
| A | GLY178 |
| A | THR179 |
| A | ARG235 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TRS A 402 |
| Chain | Residue |
| A | THR50 |
| A | GLY118 |
| A | THR121 |
| A | LYS122 |
| A | LYS125 |
| A | LYS299 |
| A | HOH560 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15753098","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15753098","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1YTK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of a zinc ion bound nicotinate phosphoribosyltransferase from Thermoplasma acidophilum.","authoringGroup":["Berkeley structural genomics center (BSGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P22253","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| A | THR107 |
