1YSB

Yeast Cytosine Deaminase Triple Mutant

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0005634cellular_componentnucleus
A0102480molecular_function5-fluorocytosine deaminase activity
A0004131molecular_functioncytosine deaminase activity
A0008270molecular_functionzinc ion binding
A0046087biological_processcytidine metabolic process
A0019858biological_processcytosine metabolic process
A0008655biological_processpyrimidine-containing compound salvage
A0044206biological_processUMP salvage
B0005737cellular_componentcytoplasm
B0005634cellular_componentnucleus
B0102480molecular_function5-fluorocytosine deaminase activity
B0004131molecular_functioncytosine deaminase activity
B0008270molecular_functionzinc ion binding
B0046087biological_processcytidine metabolic process
B0019858biological_processcytosine metabolic process
B0008655biological_processpyrimidine-containing compound salvage
B0044206biological_processUMP salvage
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC15BINDING SITE FOR RESIDUE ZN B 500
ChainResidue
BHIS262
BCYS291
BCYS294
BZN502
BHOH1332

AC25BINDING SITE FOR RESIDUE ZN A 501
ChainResidue
AHIS62
ACYS91
ACYS94
AZN503
AHOH1335

AC36BINDING SITE FOR RESIDUE ZN B 502
ChainResidue
BGLU264
BZN500
BHOH1054
BHOH1331
BHOH1332
BHOH1333

AC46BINDING SITE FOR RESIDUE ZN A 503
ChainResidue
AGLU64
AZN501
AHOH1044
AHOH1334
AHOH1335
AHOH1336

AC55BINDING SITE FOR RESIDUE CA B 504
ChainResidue
BGLY326
BASP346
BHOH1026
BHOH1065
BHOH1071

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0090374Cytidine and deoxycytidylate deaminases zinc-binding region signature. [CH]-[AGV]-E-x(2)-[LIVMFGAT]-[LIVM]-x(17,33)-P-C-x(2,8)-C-x(3)-[LIVM]
ChainResidueDetails
AHIS62-ILE98
BHIS262-ILE298

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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI11Proton donor.
ChainResidueDetails
AGLU67

SWS_FT_FI23Zinc; catalytic
ChainResidueDetails
AHIS65
ACYS94
ACYS97

SWS_FT_FI32Substrate.
ChainResidueDetails
AASN54
AASP158

SWS_FT_FI41Proton donor.
ChainResidueDetails
BGLU67

SWS_FT_FI53Zinc; catalytic
ChainResidueDetails
BHIS65
BCYS94
BCYS97

SWS_FT_FI62Substrate.
ChainResidueDetails
BASN54
BASP158

CSA13Annotated By Reference To The Literature 1uaq
ChainResidueDetails
AGLU64
ACYS91
ASER89

CSA23Annotated By Reference To The Literature 1uaq
ChainResidueDetails
BGLU264
BCYS291
BSER289

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Catalytic Information from CSA

site_idNumber of ResiduesDetails
CSA13Annotated By Reference To The Literature 1uaq
ChainResidueDetails
AGLU64
ACYS91
ASER89

CSA23Annotated By Reference To The Literature 1uaq
ChainResidueDetails
BGLU264
BCYS291
BSER289