1YS2
Burkholderia cepacia lipase complexed with hexylphosphonic acid (S) 2-methyl-3-phenylpropyl ester
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0004806 | molecular_function | triacylglycerol lipase activity |
| X | 0005576 | cellular_component | extracellular region |
| X | 0006629 | biological_process | lipid metabolic process |
| X | 0016042 | biological_process | lipid catabolic process |
| X | 0016787 | molecular_function | hydrolase activity |
| X | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA X 400 |
| Chain | Residue |
| X | ASP242 |
| X | ASP288 |
| X | GLN292 |
| X | LEU293 |
| X | VAL296 |
| X | HOH701 |
| X | HOH846 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 2HS X 600 |
| Chain | Residue |
| X | TYR29 |
| X | SER87 |
| X | GLN88 |
| X | SER117 |
| X | HIS286 |
| X | GLY16 |
| X | LEU17 |
Functional Information from PROSITE/UniProt
| site_id | PS00120 |
| Number of Residues | 10 |
| Details | LIPASE_SER Lipases, serine active site. VNLVGHSQGG |
| Chain | Residue | Details |
| X | VAL81-GLY90 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 212 |
| Details | Domain: {"description":"AB hydrolase-1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"11453990","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15850979","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18386861","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9032073","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9032074","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9660188","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1HQD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11453990","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9032073","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9032074","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9660188","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11453990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15850979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18386861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9660188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HQD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LIP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11453990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15850979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18386861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9032073","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9032074","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9660188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HQD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OIL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1tah |
| Chain | Residue | Details |
| X | ASP264 | |
| X | HIS286 | |
| X | SER87 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1tah |
| Chain | Residue | Details |
| X | ASP264 | |
| X | HIS286 | |
| X | LEU17 | |
| X | GLN88 | |
| X | SER87 |
