Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1YR3

Escherichia coli purine nucleoside phosphorylase II, the product of the xapA gene

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0005737	cellular_component	cytoplasm
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006148	biological_process	inosine catabolic process
A	0006149	biological_process	deoxyinosine catabolic process
A	0006152	biological_process	purine nucleoside catabolic process
A	0006161	biological_process	deoxyguanosine catabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0015949	biological_process	nucleobase-containing small molecule interconversion
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0034214	biological_process	protein hexamerization
A	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
A	0042802	molecular_function	identical protein binding
A	0046115	biological_process	guanosine catabolic process
A	0047724	molecular_function	inosine nucleosidase activity
A	0047975	molecular_function	guanosine phosphorylase activity
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	1903228	biological_process	xanthosine catabolic process
B	0003824	molecular_function	catalytic activity
B	0004731	molecular_function	purine-nucleoside phosphorylase activity
B	0005737	cellular_component	cytoplasm
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006148	biological_process	inosine catabolic process
B	0006149	biological_process	deoxyinosine catabolic process
B	0006152	biological_process	purine nucleoside catabolic process
B	0006161	biological_process	deoxyguanosine catabolic process
B	0009116	biological_process	nucleoside metabolic process
B	0015949	biological_process	nucleobase-containing small molecule interconversion
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0034214	biological_process	protein hexamerization
B	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
B	0042802	molecular_function	identical protein binding
B	0046115	biological_process	guanosine catabolic process
B	0047724	molecular_function	inosine nucleosidase activity
B	0047975	molecular_function	guanosine phosphorylase activity
B	0055086	biological_process	nucleobase-containing small molecule metabolic process
B	1903228	biological_process	xanthosine catabolic process
C	0003824	molecular_function	catalytic activity
C	0004731	molecular_function	purine-nucleoside phosphorylase activity
C	0005737	cellular_component	cytoplasm
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006148	biological_process	inosine catabolic process
C	0006149	biological_process	deoxyinosine catabolic process
C	0006152	biological_process	purine nucleoside catabolic process
C	0006161	biological_process	deoxyguanosine catabolic process
C	0009116	biological_process	nucleoside metabolic process
C	0015949	biological_process	nucleobase-containing small molecule interconversion
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0034214	biological_process	protein hexamerization
C	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
C	0042802	molecular_function	identical protein binding
C	0046115	biological_process	guanosine catabolic process
C	0047724	molecular_function	inosine nucleosidase activity
C	0047975	molecular_function	guanosine phosphorylase activity
C	0055086	biological_process	nucleobase-containing small molecule metabolic process
C	1903228	biological_process	xanthosine catabolic process
D	0003824	molecular_function	catalytic activity
D	0004731	molecular_function	purine-nucleoside phosphorylase activity
D	0005737	cellular_component	cytoplasm
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006148	biological_process	inosine catabolic process
D	0006149	biological_process	deoxyinosine catabolic process
D	0006152	biological_process	purine nucleoside catabolic process
D	0006161	biological_process	deoxyguanosine catabolic process
D	0009116	biological_process	nucleoside metabolic process
D	0015949	biological_process	nucleobase-containing small molecule interconversion
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0034214	biological_process	protein hexamerization
D	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
D	0042802	molecular_function	identical protein binding
D	0046115	biological_process	guanosine catabolic process
D	0047724	molecular_function	inosine nucleosidase activity
D	0047975	molecular_function	guanosine phosphorylase activity
D	0055086	biological_process	nucleobase-containing small molecule metabolic process
D	1903228	biological_process	xanthosine catabolic process
E	0003824	molecular_function	catalytic activity
E	0004731	molecular_function	purine-nucleoside phosphorylase activity
E	0005737	cellular_component	cytoplasm
E	0006139	biological_process	nucleobase-containing compound metabolic process
E	0006148	biological_process	inosine catabolic process
E	0006149	biological_process	deoxyinosine catabolic process
E	0006152	biological_process	purine nucleoside catabolic process
E	0006161	biological_process	deoxyguanosine catabolic process
E	0009116	biological_process	nucleoside metabolic process
E	0015949	biological_process	nucleobase-containing small molecule interconversion
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0034214	biological_process	protein hexamerization
E	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
E	0042802	molecular_function	identical protein binding
E	0046115	biological_process	guanosine catabolic process
E	0047724	molecular_function	inosine nucleosidase activity
E	0047975	molecular_function	guanosine phosphorylase activity
E	0055086	biological_process	nucleobase-containing small molecule metabolic process
E	1903228	biological_process	xanthosine catabolic process
F	0003824	molecular_function	catalytic activity
F	0004731	molecular_function	purine-nucleoside phosphorylase activity
F	0005737	cellular_component	cytoplasm
F	0006139	biological_process	nucleobase-containing compound metabolic process
F	0006148	biological_process	inosine catabolic process
F	0006149	biological_process	deoxyinosine catabolic process
F	0006152	biological_process	purine nucleoside catabolic process
F	0006161	biological_process	deoxyguanosine catabolic process
F	0009116	biological_process	nucleoside metabolic process
F	0015949	biological_process	nucleobase-containing small molecule interconversion
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0034214	biological_process	protein hexamerization
F	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
F	0042802	molecular_function	identical protein binding
F	0046115	biological_process	guanosine catabolic process
F	0047724	molecular_function	inosine nucleosidase activity
F	0047975	molecular_function	guanosine phosphorylase activity
F	0055086	biological_process	nucleobase-containing small molecule metabolic process
F	1903228	biological_process	xanthosine catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 500

Chain	Residue
A	GLY33
A	SER34
A	HIS65
A	ARG85
A	HIS87
A	ASN116
A	ALA117
A	SER216

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 501

Chain	Residue
B	SER34
B	HIS65
B	ARG85
B	HIS87
B	ASN116
B	ALA117
B	SER216
B	GLY33

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 502

Chain	Residue
C	GLY33
C	SER34
C	HIS65
C	ARG85
C	HIS87
C	ASN116
C	ALA117
C	SER216

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 503

Chain	Residue
D	GLY33
D	SER34
D	HIS65
D	ARG85
D	HIS87
D	ASN116
D	ALA117
D	SER216

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 E 504

Chain	Residue
E	GLY33
E	SER34
E	HIS65
E	ARG85
E	HIS87
E	ASN116
E	ALA117
E	SER216

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 F 505

Chain	Residue
F	GLY33
F	SER34
F	HIS65
F	ARG85
F	HIS87
F	ASN116
F	ALA117
F	SER216

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE XAN A 400

Chain	Residue
A	ALA117
A	ALA118
A	GLU197
A	GLY214
A	MET215
A	THR238
A	ASN239
A	LEU249

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE XAN B 401

Chain	Residue
B	ALA117
B	ALA118
B	GLU197
B	GLY214
B	MET215
B	THR238
B	ASN239
B	LEU249

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE XAN C 402

Chain	Residue
C	ALA117
C	ALA118
C	GLU197
C	GLY214
C	MET215
C	THR238
C	ASN239
C	LEU249

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE XAN D 403

Chain	Residue
D	ALA117
D	ALA118
D	GLU197
D	GLY214
D	MET215
D	THR238
D	ASN239
D	LEU249

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE XAN E 404

Chain	Residue
E	ALA117
E	ALA118
E	GLU197
E	GLY214
E	MET215
E	THR238
E	ASN239
E	LEU249

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE XAN F 405

Chain	Residue
F	ALA117
F	ALA118
F	GLU197
F	GLY214
F	MET215
F	THR238
F	ASN239
F	LEU249

Functional Information from PROSITE/UniProt

site_id	PS01240
Number of Residues	42
Details	PNP_MTAP_2 Purine and other phosphorylases family 2 signature. VcmkGrgHfYegrgMtimTdaIrTfkllGcel.LFctNAaGSL

Chain	Residue	Details
A	VAL80-LEU121

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15808857","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YQQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15808857","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YQU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15808857","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
A	GLU90
A	HIS87
A	ASN239

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
D	ASP246
D	ASN239

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
E	ASP246
E	ASN239

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
F	ASP246
F	ASN239

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
B	GLU90
B	HIS87
B	ASN239

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
C	GLU90
C	HIS87
C	ASN239

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
D	GLU90
D	HIS87
D	ASN239

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
E	GLU90
E	HIS87
E	ASN239

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
F	GLU90
F	HIS87
F	ASN239

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
A	ASP246
A	ASN239

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
B	ASP246
B	ASN239

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
C	ASP246
C	ASN239

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)