1YQN
E. coli ispF double mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0006744 | biological_process | ubiquinone biosynthetic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0008685 | molecular_function | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 400 |
| Chain | Residue |
| A | ASP8 |
| A | HIS10 |
| A | HIS42 |
| A | CDP200 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 500 |
| Chain | Residue |
| A | GLU135 |
| A | CDP200 |
| A | HOH607 |
| A | HOH608 |
| A | HOH609 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE CDP A 200 |
| Chain | Residue |
| A | ASP8 |
| A | HIS10 |
| A | HIS42 |
| A | ASP56 |
| A | ILE57 |
| A | GLY58 |
| A | ALA100 |
| A | PRO103 |
| A | LYS104 |
| A | MET105 |
| A | LEU106 |
| A | ALA131 |
| A | THR132 |
| A | THR133 |
| A | GLU135 |
| A | ZN400 |
| A | MN500 |
| A | HOH607 |
| A | HOH608 |
| A | HOH609 |
| A | HOH617 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GPP A 300 |
| Chain | Residue |
| A | PHE7 |
| A | PHE7 |
| A | GLY138 |
| A | GLY138 |
| A | GLY138 |
| A | PHE139 |
| A | PHE139 |
| A | PHE139 |
| A | GLU149 |
| A | GLU149 |
| A | GLU149 |
Functional Information from PROSITE/UniProt
| site_id | PS01350 |
| Number of Residues | 16 |
| Details | ISPF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. SDGDVAlHAltDAllG |
| Chain | Residue | Details |
| A | SER35-GLY50 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11786530, ECO:0000269|PubMed:11829504, ECO:0000269|PubMed:11997478, ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0000269|PubMed:16511114, ECO:0000269|PubMed:19320487, ECO:0007744|PDB:1GX1, ECO:0007744|PDB:1H47, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1JY8, ECO:0007744|PDB:1U3L, ECO:0007744|PDB:1U3P, ECO:0007744|PDB:1U40, ECO:0007744|PDB:1YQN, ECO:0007744|PDB:2AMT, ECO:0007744|PDB:2GZL, ECO:0007744|PDB:3ELC, ECO:0007744|PDB:3EOR, ECO:0007744|PDB:3ERN, ECO:0007744|PDB:3ESJ, ECO:0007744|PDB:3FBA |
| Chain | Residue | Details |
| A | ASP8 | |
| A | HIS10 | |
| A | HIS42 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11786530, ECO:0000269|PubMed:11829504, ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1KNJ, ECO:0007744|PDB:1U43, ECO:0007744|PDB:2AMT |
| Chain | Residue | Details |
| A | HIS34 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11829504, ECO:0000269|PubMed:11997478, ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0000269|PubMed:16511114, ECO:0000269|PubMed:19320487, ECO:0000312|PDB:1U43, ECO:0007744|PDB:1GX1, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1U3L, ECO:0007744|PDB:1U3P, ECO:0007744|PDB:1YQN, ECO:0007744|PDB:2AMT, ECO:0007744|PDB:2GZL, ECO:0007744|PDB:3ERN |
| Chain | Residue | Details |
| A | ASP56 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11829504, ECO:0000269|PubMed:15608374, ECO:0000312|PDB:1JY8, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1U3P, ECO:0007744|PDB:1U40 |
| Chain | Residue | Details |
| A | PHE61 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11786530, ECO:0000269|PubMed:11997478, ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0000269|PubMed:19320487, ECO:0007744|PDB:1GX1, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1KNJ, ECO:0007744|PDB:1U3L, ECO:0007744|PDB:1YQN, ECO:0007744|PDB:2AMT, ECO:0007744|PDB:3ELC, ECO:0007744|PDB:3EOR, ECO:0007744|PDB:3ERN, ECO:0007744|PDB:3ESJ, ECO:0007744|PDB:3FBA |
| Chain | Residue | Details |
| A | ALA100 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11997478, ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0000269|PubMed:19320487, ECO:0007744|PDB:1GX1, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1U3L, ECO:0007744|PDB:1YQN, ECO:0007744|PDB:2AMT, ECO:0007744|PDB:3ERN |
| Chain | Residue | Details |
| A | THR132 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0000269|PubMed:16511114, ECO:0000269|PubMed:19320487, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1YQN, ECO:0007744|PDB:2AMT, ECO:0007744|PDB:3ELC, ECO:0007744|PDB:3ERN |
| Chain | Residue | Details |
| A | PHE139 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0000269|PubMed:19320487, ECO:0000312|PDB:3ELC, ECO:0007744|PDB:1H48, ECO:0007744|PDB:2AMT, ECO:0007744|PDB:2GZL, ECO:0007744|PDB:3EOR, ECO:0007744|PDB:3ERN, ECO:0007744|PDB:3ESJ, ECO:0007744|PDB:3FBA |
| Chain | Residue | Details |
| A | MET142 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00107, ECO:0000305|PubMed:11786530 |
| Chain | Residue | Details |
| A | HIS34 | |
| A | THR133 |
