Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
| site_id | APL |
| Number of Residues | 9 |
| Details | THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES |
| Chain | Residue |
| A | HIS402 |
| A | CYS403 |
| A | ARG404 |
| A | ALA405 |
| A | GLY406 |
| A | VAL407 |
| A | GLY408 |
| A | ARG409 |
| A | THR410 |
| site_id | BPL |
| Number of Residues | 9 |
| Details | THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES |
| Chain | Residue |
| B | HIS402 |
| B | CYS403 |
| B | ARG404 |
| B | ALA405 |
| B | GLY406 |
| B | VAL407 |
| B | GLY408 |
| B | ARG409 |
| B | THR410 |
| site_id | WPD |
| Number of Residues | 11 |
| Details | THE FLEXIBLE LOOP FROM MOLECULE B CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE TUNGSTATE ANION IN THE TUNGSTATE-BOUND STRUCTURE. |
| Chain | Residue |
| B | HIS350 |
| B | VAL351 |
| B | GLY352 |
| B | ASN353 |
| B | TRP354 |
| B | PRO355 |
| B | ASP356 |
| B | GLN357 |
| B | THR358 |
| B | ALA359 |
| B | VAL360 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCraGvgRTA |
| Chain | Residue | Details |
| A | ILE401-ALA411 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Phosphocysteine intermediate |
| Chain | Residue | Details |
| A | CYS403 | |
| B | CYS403 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 47 |
| Chain | Residue | Details |
| A | GLU290 | steric role |
| A | TRP354 | steric role |
| A | ASP356 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | HIS402 | electrostatic stabiliser, hydrogen bond donor |
| A | CYS403 | nucleofuge, nucleophile |
| A | ARG409 | electrostatic stabiliser, hydrogen bond donor |
| A | THR410 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 47 |
| Chain | Residue | Details |
| B | GLU290 | steric role |
| B | TRP354 | steric role |
| B | ASP356 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | HIS402 | electrostatic stabiliser, hydrogen bond donor |
| B | CYS403 | nucleofuge, nucleophile |
| B | ARG409 | electrostatic stabiliser, hydrogen bond donor |
| B | THR410 | electrostatic stabiliser, hydrogen bond donor |
