Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002088 | biological_process | lens development in camera-type eye |
| A | 0005212 | molecular_function | structural constituent of eye lens |
| A | 0005516 | molecular_function | calmodulin binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005921 | cellular_component | gap junction |
| A | 0006833 | biological_process | water transport |
| A | 0007601 | biological_process | visual perception |
| A | 0015250 | molecular_function | water channel activity |
| A | 0015267 | molecular_function | channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0045785 | biological_process | positive regulation of cell adhesion |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0055085 | biological_process | transmembrane transport |
| A | 1990349 | biological_process | gap junction-mediated intercellular transport |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGAGLGSLLYdFllfprlksvserl.....SILK |
| Chain | Residue | Details |
| A | ILE210-LYS238 | |
| site_id | PS00221 |
| Number of Residues | 9 |
| Details | MIP MIP family signature. HVNPAVTFA |
| Chain | Residue | Details |
| A | HIS66-ALA74 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 66 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | MET1-SER8 | |
| A | SER79-LEU84 | |
| A | THR148-SER159 | |
| A | ASP220-LEU263 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 121 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | PHE9-LEU32 | |
| A | LEU39-HIS61 | |
| A | ARG85-VAL107 | |
| A | VAL127-ALA147 | |
| A | VAL160-MET176 | |
| A | HIS201-TYR219 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | TOPO_DOM: Extracellular |
| Chain | Residue | Details |
| A | ARG33-PRO38 | |
| A | THR108-SER126 | |
| A | THR195-ASN200 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 11 |
| Details | INTRAMEM: |
| Chain | Residue | Details |
| A | ILE62-VAL67 | |
| A | TYR177-MET183 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | INTRAMEM: Helical |
| Chain | Residue | Details |
| A | ASN68-GLY78 | |
| A | ASN184-LEU194 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Important for water channel gating |
| Chain | Residue | Details |
| A | TYR149 | |
| Chain | Residue | Details |
| A | ASN246 | |
| Chain | Residue | Details |
| A | GLU250 | |
| Chain | Residue | Details |
| A | SER235 | |
| Chain | Residue | Details |
| A | SER243 | |
| Chain | Residue | Details |
| A | SER245 | |
| Chain | Residue | Details |
| A | ASN246 | |
