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1YM7

G Protein-Coupled Receptor Kinase 2 (GRK2)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001664molecular_functionG protein-coupled receptor binding
A0002026biological_processregulation of the force of heart contraction
A0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
A0002031biological_processG protein-coupled receptor internalization
A0003108biological_processnegative regulation of the force of heart contraction by chemical signal
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004703molecular_functionG protein-coupled receptor kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006468biological_processprotein phosphorylation
A0006886biological_processintracellular protein transport
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
A0009966biological_processregulation of signal transduction
A0016020cellular_componentmembrane
A0018105biological_processpeptidyl-serine phosphorylation
A0031694molecular_functionalpha-2A adrenergic receptor binding
A0031755molecular_functionEdg-2 lysophosphatidic acid receptor binding
A0042995cellular_componentcell projection
A0045202cellular_componentsynapse
A0045880biological_processpositive regulation of smoothened signaling pathway
A0045988biological_processnegative regulation of striated muscle contraction
A0047696molecular_functionbeta-adrenergic receptor kinase activity
A0060048biological_processcardiac muscle contraction
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A1901081biological_processnegative regulation of relaxation of smooth muscle
A1903566biological_processpositive regulation of protein localization to cilium
B0001664molecular_functionG protein-coupled receptor binding
B0002026biological_processregulation of the force of heart contraction
B0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
B0002031biological_processG protein-coupled receptor internalization
B0003108biological_processnegative regulation of the force of heart contraction by chemical signal
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004703molecular_functionG protein-coupled receptor kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006468biological_processprotein phosphorylation
B0006886biological_processintracellular protein transport
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0009966biological_processregulation of signal transduction
B0016020cellular_componentmembrane
B0018105biological_processpeptidyl-serine phosphorylation
B0031694molecular_functionalpha-2A adrenergic receptor binding
B0031755molecular_functionEdg-2 lysophosphatidic acid receptor binding
B0042995cellular_componentcell projection
B0045202cellular_componentsynapse
B0045880biological_processpositive regulation of smoothened signaling pathway
B0045988biological_processnegative regulation of striated muscle contraction
B0047696molecular_functionbeta-adrenergic receptor kinase activity
B0060048biological_processcardiac muscle contraction
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B1901081biological_processnegative regulation of relaxation of smooth muscle
B1903566biological_processpositive regulation of protein localization to cilium
C0001664molecular_functionG protein-coupled receptor binding
C0002026biological_processregulation of the force of heart contraction
C0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
C0002031biological_processG protein-coupled receptor internalization
C0003108biological_processnegative regulation of the force of heart contraction by chemical signal
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004703molecular_functionG protein-coupled receptor kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006468biological_processprotein phosphorylation
C0006886biological_processintracellular protein transport
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
C0009966biological_processregulation of signal transduction
C0016020cellular_componentmembrane
C0018105biological_processpeptidyl-serine phosphorylation
C0031694molecular_functionalpha-2A adrenergic receptor binding
C0031755molecular_functionEdg-2 lysophosphatidic acid receptor binding
C0042995cellular_componentcell projection
C0045202cellular_componentsynapse
C0045880biological_processpositive regulation of smoothened signaling pathway
C0045988biological_processnegative regulation of striated muscle contraction
C0047696molecular_functionbeta-adrenergic receptor kinase activity
C0060048biological_processcardiac muscle contraction
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C1901081biological_processnegative regulation of relaxation of smooth muscle
C1903566biological_processpositive regulation of protein localization to cilium
D0001664molecular_functionG protein-coupled receptor binding
D0002026biological_processregulation of the force of heart contraction
D0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
D0002031biological_processG protein-coupled receptor internalization
D0003108biological_processnegative regulation of the force of heart contraction by chemical signal
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004703molecular_functionG protein-coupled receptor kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006468biological_processprotein phosphorylation
D0006886biological_processintracellular protein transport
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
D0009966biological_processregulation of signal transduction
D0016020cellular_componentmembrane
D0018105biological_processpeptidyl-serine phosphorylation
D0031694molecular_functionalpha-2A adrenergic receptor binding
D0031755molecular_functionEdg-2 lysophosphatidic acid receptor binding
D0042995cellular_componentcell projection
D0045202cellular_componentsynapse
D0045880biological_processpositive regulation of smoothened signaling pathway
D0045988biological_processnegative regulation of striated muscle contraction
D0047696molecular_functionbeta-adrenergic receptor kinase activity
D0060048biological_processcardiac muscle contraction
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D1901081biological_processnegative regulation of relaxation of smooth muscle
D1903566biological_processpositive regulation of protein localization to cilium
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGGFGEVYgCrkadtgkm..........YAMK
ChainResidueDetails
AILE197-LYS220

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKpaNILL
ChainResidueDetails
AVAL313-LEU325

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP317
BASP317
CASP317
DASP317

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE197
ALYS220
BILE197
BLYS220
CILE197
CLYS220
DILE197
DLYS220

site_idSWS_FT_FI3
Number of Residues12
DetailsSITE: Required for receptor phosphorylation => ECO:0000250|UniProtKB:P25098
ChainResidueDetails
AASP3
DASP3
DLEU4
DASP10
ALEU4
AASP10
BASP3
BLEU4
BASP10
CASP3
CLEU4
CASP10

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P25098
ChainResidueDetails
AALA670
BALA670
CALA670
DALA670

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP317
AALA321

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASP317
BALA321

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP317
CALA321

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DASP317
DALA321

site_idCSA5
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP317
ALYS319

site_idCSA6
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASP317
BLYS319

site_idCSA7
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP317
CLYS319

site_idCSA8
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DASP317
DLYS319

site_idCSA9
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
ATHR353
AASP317
ALYS319

site_idCSA10
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BTHR353
BASP317
BLYS319

site_idCSA11
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CTHR353
CASP317
CLYS319

site_idCSA12
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DTHR353
DASP317
DLYS319

site_idCSA13
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP317
ALYS319
AASN322

site_idCSA14
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASP317
BLYS319
BASN322

site_idCSA15
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP317
CLYS319
CASN322

site_idCSA16
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DASP317
DLYS319
DASN322

219140

PDB entries from 2024-05-01

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