Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1YM7

G Protein-Coupled Receptor Kinase 2 (GRK2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001664	molecular_function	G protein-coupled receptor binding
A	0002026	biological_process	regulation of the force of heart contraction
A	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
A	0002031	biological_process	G protein-coupled receptor internalization
A	0003108	biological_process	negative regulation of the force of heart contraction by chemical signal
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004703	molecular_function	G protein-coupled receptor kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006468	biological_process	protein phosphorylation
A	0006886	biological_process	intracellular protein transport
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
A	0007217	biological_process	tachykinin receptor signaling pathway
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019079	biological_process	viral genome replication
A	0031623	biological_process	receptor internalization
A	0031694	molecular_function	alpha-2A adrenergic receptor binding
A	0031755	molecular_function	Edg-2 lysophosphatidic acid receptor binding
A	0032473	cellular_component	cytoplasmic side of mitochondrial outer membrane
A	0045880	biological_process	positive regulation of smoothened signaling pathway
A	0045988	biological_process	negative regulation of striated muscle contraction
A	0046718	biological_process	symbiont entry into host cell
A	0047696	molecular_function	beta-adrenergic receptor kinase activity
A	0060048	biological_process	cardiac muscle contraction
A	0071880	biological_process	adenylate cyclase-activating adrenergic receptor signaling pathway
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	1901081	biological_process	negative regulation of relaxation of smooth muscle
A	1903566	biological_process	positive regulation of protein localization to cilium
B	0000166	molecular_function	nucleotide binding
B	0001664	molecular_function	G protein-coupled receptor binding
B	0002026	biological_process	regulation of the force of heart contraction
B	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
B	0002031	biological_process	G protein-coupled receptor internalization
B	0003108	biological_process	negative regulation of the force of heart contraction by chemical signal
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004703	molecular_function	G protein-coupled receptor kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006468	biological_process	protein phosphorylation
B	0006886	biological_process	intracellular protein transport
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
B	0007217	biological_process	tachykinin receptor signaling pathway
B	0009966	biological_process	regulation of signal transduction
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019079	biological_process	viral genome replication
B	0031623	biological_process	receptor internalization
B	0031694	molecular_function	alpha-2A adrenergic receptor binding
B	0031755	molecular_function	Edg-2 lysophosphatidic acid receptor binding
B	0032473	cellular_component	cytoplasmic side of mitochondrial outer membrane
B	0045880	biological_process	positive regulation of smoothened signaling pathway
B	0045988	biological_process	negative regulation of striated muscle contraction
B	0046718	biological_process	symbiont entry into host cell
B	0047696	molecular_function	beta-adrenergic receptor kinase activity
B	0060048	biological_process	cardiac muscle contraction
B	0071880	biological_process	adenylate cyclase-activating adrenergic receptor signaling pathway
B	0098793	cellular_component	presynapse
B	0098794	cellular_component	postsynapse
B	1901081	biological_process	negative regulation of relaxation of smooth muscle
B	1903566	biological_process	positive regulation of protein localization to cilium
C	0000166	molecular_function	nucleotide binding
C	0001664	molecular_function	G protein-coupled receptor binding
C	0002026	biological_process	regulation of the force of heart contraction
C	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
C	0002031	biological_process	G protein-coupled receptor internalization
C	0003108	biological_process	negative regulation of the force of heart contraction by chemical signal
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004703	molecular_function	G protein-coupled receptor kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006468	biological_process	protein phosphorylation
C	0006886	biological_process	intracellular protein transport
C	0007165	biological_process	signal transduction
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
C	0007217	biological_process	tachykinin receptor signaling pathway
C	0009966	biological_process	regulation of signal transduction
C	0016020	cellular_component	membrane
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019079	biological_process	viral genome replication
C	0031623	biological_process	receptor internalization
C	0031694	molecular_function	alpha-2A adrenergic receptor binding
C	0031755	molecular_function	Edg-2 lysophosphatidic acid receptor binding
C	0032473	cellular_component	cytoplasmic side of mitochondrial outer membrane
C	0045880	biological_process	positive regulation of smoothened signaling pathway
C	0045988	biological_process	negative regulation of striated muscle contraction
C	0046718	biological_process	symbiont entry into host cell
C	0047696	molecular_function	beta-adrenergic receptor kinase activity
C	0060048	biological_process	cardiac muscle contraction
C	0071880	biological_process	adenylate cyclase-activating adrenergic receptor signaling pathway
C	0098793	cellular_component	presynapse
C	0098794	cellular_component	postsynapse
C	1901081	biological_process	negative regulation of relaxation of smooth muscle
C	1903566	biological_process	positive regulation of protein localization to cilium
D	0000166	molecular_function	nucleotide binding
D	0001664	molecular_function	G protein-coupled receptor binding
D	0002026	biological_process	regulation of the force of heart contraction
D	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
D	0002031	biological_process	G protein-coupled receptor internalization
D	0003108	biological_process	negative regulation of the force of heart contraction by chemical signal
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004703	molecular_function	G protein-coupled receptor kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006468	biological_process	protein phosphorylation
D	0006886	biological_process	intracellular protein transport
D	0007165	biological_process	signal transduction
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
D	0007217	biological_process	tachykinin receptor signaling pathway
D	0009966	biological_process	regulation of signal transduction
D	0016020	cellular_component	membrane
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0019079	biological_process	viral genome replication
D	0031623	biological_process	receptor internalization
D	0031694	molecular_function	alpha-2A adrenergic receptor binding
D	0031755	molecular_function	Edg-2 lysophosphatidic acid receptor binding
D	0032473	cellular_component	cytoplasmic side of mitochondrial outer membrane
D	0045880	biological_process	positive regulation of smoothened signaling pathway
D	0045988	biological_process	negative regulation of striated muscle contraction
D	0046718	biological_process	symbiont entry into host cell
D	0047696	molecular_function	beta-adrenergic receptor kinase activity
D	0060048	biological_process	cardiac muscle contraction
D	0071880	biological_process	adenylate cyclase-activating adrenergic receptor signaling pathway
D	0098793	cellular_component	presynapse
D	0098794	cellular_component	postsynapse
D	1901081	biological_process	negative regulation of relaxation of smooth muscle
D	1903566	biological_process	positive regulation of protein localization to cilium

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGGFGEVYgCrkadtgkm..........YAMK

Chain	Residue	Details
A	ILE197-LYS220

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKpaNILL

Chain	Residue	Details
A	VAL313-LEU325

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	484
Details	Domain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1048
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP317
A	ALA321

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	THR353
B	ASP317
B	LYS319

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	THR353
C	ASP317
C	LYS319

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	THR353
D	ASP317
D	LYS319

site_id	CSA13
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP317
A	LYS319
A	ASN322

site_id	CSA14
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP317
B	LYS319
B	ASN322

site_id	CSA15
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP317
C	LYS319
C	ASN322

site_id	CSA16
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP317
D	LYS319
D	ASN322

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP317
B	ALA321

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP317
C	ALA321

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP317
D	ALA321

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP317
A	LYS319

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP317
B	LYS319

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP317
C	LYS319

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP317
D	LYS319

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	THR353
A	ASP317
A	LYS319

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)