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1YLD

Trypsin/BPTI complex mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0007584biological_processresponse to nutrient
A0007586biological_processdigestion
A0008236molecular_functionserine-type peptidase activity
A0030574biological_processcollagen catabolic process
A0046872molecular_functionmetal ion binding
B0004867molecular_functionserine-type endopeptidase inhibitor activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 800
ChainResidue
AGLU70
AASN72
AVAL75
AGLU77
AGLU80
AHOH526

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 990
ChainResidue
BHOH664
BLYS41
BARG42
BHOH529

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 B 991
ChainResidue
BARG20
BTYR35
BALA40
BHOH639
BHOH687
BHOH705

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
ChainResidueDetails
AVAL53-CYS58

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Reactive bond for trypsin
ChainResidueDetails
BLYS15
AASP102
AALA195

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AGLU70
AASN72
AVAL75
AGLU80

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Required for specificity => ECO:0000250
ChainResidueDetails
AASP189

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
AHIS57

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
AALA195
AGLY196

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
AALA195
AGLY193

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
AALA195
AHIS57

site_idCSA5
Number of Residues4
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
AALA195
AGLY193
AHIS57

site_idCSA6
Number of Residues7
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
AGLN192
AASP102
AALA195
AGLY193
ACYS191
AHIS57
AASP194

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PDB entries from 2024-11-06

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