Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1YJX

Crystal structure of human B type phosphoglycerate mutase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004082	molecular_function	bisphosphoglycerate mutase activity
A	0004619	molecular_function	phosphoglycerate mutase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016853	molecular_function	isomerase activity
A	0016868	molecular_function	intramolecular phosphotransferase activity
A	0019901	molecular_function	protein kinase binding
A	0034774	cellular_component	secretory granule lumen
A	0061621	biological_process	canonical glycolysis
A	0070062	cellular_component	extracellular exosome
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0003824	molecular_function	catalytic activity
B	0004082	molecular_function	bisphosphoglycerate mutase activity
B	0004619	molecular_function	phosphoglycerate mutase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016853	molecular_function	isomerase activity
B	0016868	molecular_function	intramolecular phosphotransferase activity
B	0019901	molecular_function	protein kinase binding
B	0034774	cellular_component	secretory granule lumen
B	0061621	biological_process	canonical glycolysis
B	0070062	cellular_component	extracellular exosome
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0003824	molecular_function	catalytic activity
C	0004082	molecular_function	bisphosphoglycerate mutase activity
C	0004619	molecular_function	phosphoglycerate mutase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016853	molecular_function	isomerase activity
C	0016868	molecular_function	intramolecular phosphotransferase activity
C	0019901	molecular_function	protein kinase binding
C	0034774	cellular_component	secretory granule lumen
C	0061621	biological_process	canonical glycolysis
C	0070062	cellular_component	extracellular exosome
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0003824	molecular_function	catalytic activity
D	0004082	molecular_function	bisphosphoglycerate mutase activity
D	0004619	molecular_function	phosphoglycerate mutase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0016853	molecular_function	isomerase activity
D	0016868	molecular_function	intramolecular phosphotransferase activity
D	0019901	molecular_function	protein kinase binding
D	0034774	cellular_component	secretory granule lumen
D	0061621	biological_process	canonical glycolysis
D	0070062	cellular_component	extracellular exosome
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0003824	molecular_function	catalytic activity
E	0004082	molecular_function	bisphosphoglycerate mutase activity
E	0004619	molecular_function	phosphoglycerate mutase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006094	biological_process	gluconeogenesis
E	0006096	biological_process	glycolytic process
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0016853	molecular_function	isomerase activity
E	0016868	molecular_function	intramolecular phosphotransferase activity
E	0019901	molecular_function	protein kinase binding
E	0034774	cellular_component	secretory granule lumen
E	0061621	biological_process	canonical glycolysis
E	0070062	cellular_component	extracellular exosome
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0003824	molecular_function	catalytic activity
F	0004082	molecular_function	bisphosphoglycerate mutase activity
F	0004619	molecular_function	phosphoglycerate mutase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006094	biological_process	gluconeogenesis
F	0006096	biological_process	glycolytic process
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0016853	molecular_function	isomerase activity
F	0016868	molecular_function	intramolecular phosphotransferase activity
F	0019901	molecular_function	protein kinase binding
F	0034774	cellular_component	secretory granule lumen
F	0061621	biological_process	canonical glycolysis
F	0070062	cellular_component	extracellular exosome
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0003824	molecular_function	catalytic activity
G	0004082	molecular_function	bisphosphoglycerate mutase activity
G	0004619	molecular_function	phosphoglycerate mutase activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006094	biological_process	gluconeogenesis
G	0006096	biological_process	glycolytic process
G	0016020	cellular_component	membrane
G	0016787	molecular_function	hydrolase activity
G	0016853	molecular_function	isomerase activity
G	0016868	molecular_function	intramolecular phosphotransferase activity
G	0019901	molecular_function	protein kinase binding
G	0034774	cellular_component	secretory granule lumen
G	0061621	biological_process	canonical glycolysis
G	0070062	cellular_component	extracellular exosome
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0003824	molecular_function	catalytic activity
H	0004082	molecular_function	bisphosphoglycerate mutase activity
H	0004619	molecular_function	phosphoglycerate mutase activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006094	biological_process	gluconeogenesis
H	0006096	biological_process	glycolytic process
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0016853	molecular_function	isomerase activity
H	0016868	molecular_function	intramolecular phosphotransferase activity
H	0019901	molecular_function	protein kinase binding
H	0034774	cellular_component	secretory granule lumen
H	0061621	biological_process	canonical glycolysis
H	0070062	cellular_component	extracellular exosome
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0003824	molecular_function	catalytic activity
I	0004082	molecular_function	bisphosphoglycerate mutase activity
I	0004619	molecular_function	phosphoglycerate mutase activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006094	biological_process	gluconeogenesis
I	0006096	biological_process	glycolytic process
I	0016020	cellular_component	membrane
I	0016787	molecular_function	hydrolase activity
I	0016853	molecular_function	isomerase activity
I	0016868	molecular_function	intramolecular phosphotransferase activity
I	0019901	molecular_function	protein kinase binding
I	0034774	cellular_component	secretory granule lumen
I	0061621	biological_process	canonical glycolysis
I	0070062	cellular_component	extracellular exosome
I	1904813	cellular_component	ficolin-1-rich granule lumen
J	0003824	molecular_function	catalytic activity
J	0004082	molecular_function	bisphosphoglycerate mutase activity
J	0004619	molecular_function	phosphoglycerate mutase activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006094	biological_process	gluconeogenesis
J	0006096	biological_process	glycolytic process
J	0016020	cellular_component	membrane
J	0016787	molecular_function	hydrolase activity
J	0016853	molecular_function	isomerase activity
J	0016868	molecular_function	intramolecular phosphotransferase activity
J	0019901	molecular_function	protein kinase binding
J	0034774	cellular_component	secretory granule lumen
J	0061621	biological_process	canonical glycolysis
J	0070062	cellular_component	extracellular exosome
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0003824	molecular_function	catalytic activity
K	0004082	molecular_function	bisphosphoglycerate mutase activity
K	0004619	molecular_function	phosphoglycerate mutase activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006094	biological_process	gluconeogenesis
K	0006096	biological_process	glycolytic process
K	0016020	cellular_component	membrane
K	0016787	molecular_function	hydrolase activity
K	0016853	molecular_function	isomerase activity
K	0016868	molecular_function	intramolecular phosphotransferase activity
K	0019901	molecular_function	protein kinase binding
K	0034774	cellular_component	secretory granule lumen
K	0061621	biological_process	canonical glycolysis
K	0070062	cellular_component	extracellular exosome
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0003824	molecular_function	catalytic activity
L	0004082	molecular_function	bisphosphoglycerate mutase activity
L	0004619	molecular_function	phosphoglycerate mutase activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006094	biological_process	gluconeogenesis
L	0006096	biological_process	glycolytic process
L	0016020	cellular_component	membrane
L	0016787	molecular_function	hydrolase activity
L	0016853	molecular_function	isomerase activity
L	0016868	molecular_function	intramolecular phosphotransferase activity
L	0019901	molecular_function	protein kinase binding
L	0034774	cellular_component	secretory granule lumen
L	0061621	biological_process	canonical glycolysis
L	0070062	cellular_component	extracellular exosome
L	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 263

Chain	Residue
A	TRP68
A	ARG83
B	TRP68
B	ARG83

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 263

Chain	Residue
C	TRP68
C	ARG83
D	TRP68
D	ARG83

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL F 263

Chain	Residue
E	ARG83
F	TRP68
F	ARG83
E	TRP68

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL H 263

Chain	Residue
G	TRP68
G	ARG83
H	TRP68
H	ARG83

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL J 263

Chain	Residue
I	TRP68
I	VAL81
I	ARG83
J	TRP68
J	VAL81
J	ARG83

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL K 263

Chain	Residue
K	TRP68
K	VAL81
K	ARG83
L	TRP68
L	VAL81
L	ARG83

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CIT A 601

Chain	Residue
A	ASN17
A	SER23
A	GLY24
A	TYR92
A	LYS100
A	ARG116
A	HOH608
A	HOH616

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CIT B 602

Chain	Residue
B	ASN17
B	SER23
B	GLY24
B	GLU89
B	TYR92
B	LYS100
B	HOH605
B	HOH628

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CIT C 603

Chain	Residue
C	PHE22
C	SER23
C	GLY24
C	GLU89
C	TYR92
C	LYS100
C	ARG116
C	HOH619

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CIT D 604

Chain	Residue
D	ASN17
D	SER23
D	GLY24
D	GLU89
D	TYR92
D	LYS100
D	ARG116
D	HOH628

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CIT E 605

Chain	Residue
E	ASN17
E	SER23
E	GLY24
E	GLU89
E	TYR92
E	LYS100
E	ARG116

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CIT F 606

Chain	Residue
F	ARG10
F	PHE22
F	SER23
F	GLY24
F	GLU89
F	TYR92
F	LYS100

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CIT G 607

Chain	Residue
G	ARG10
G	SER23
G	GLY24
G	TYR92
G	LYS100

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CIT H 608

Chain	Residue
H	ASN17
H	SER23
H	GLY24
H	ARG62
H	GLU89
H	TYR92
H	LYS100

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CIT I 609

Chain	Residue
I	ARG10
I	PHE22
I	SER23
I	GLY24
I	GLU89
I	TYR92
I	LYS100
I	HOH619
I	HOH621

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CIT J 610

Chain	Residue
J	LYS100
J	ARG116
J	PHE22
J	SER23
J	GLY24
J	TYR92

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CIT K 611

Chain	Residue
K	ARG10
K	PHE22
K	SER23
K	GLY24
K	GLU89
K	TYR92
K	LYS100
K	ARG116

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CIT L 612

Chain	Residue
L	ARG10
L	ASN17
L	SER23
L	GLY24
L	TYR92
L	LYS100
L	ARG116
L	HOH628

Functional Information from PROSITE/UniProt

site_id	PS00175
Number of Residues	10
Details	PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. LiRHGEsAwN

Chain	Residue	Details
A	LEU8-ASN17

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Tele-phosphohistidine intermediate","evidences":[{"source":"PubMed","id":"23653202","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15883004","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"15883004","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	108
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15883004","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23653202","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q3JWH7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15883004","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P00950","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	12
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23653202","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DBJ1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9DBJ1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
A	HIS186
A	ARG62
A	HIS11
A	GLU89

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
J	HIS186
J	ARG62
J	HIS11
J	GLU89

site_id	CSA11
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
K	HIS186
K	ARG62
K	HIS11
K	GLU89

site_id	CSA12
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
L	HIS186
L	ARG62
L	HIS11
L	GLU89

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
B	HIS186
B	ARG62
B	HIS11
B	GLU89

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
C	HIS186
C	ARG62
C	HIS11
C	GLU89

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
D	HIS186
D	ARG62
D	HIS11
D	GLU89

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
E	HIS186
E	ARG62
E	HIS11
E	GLU89

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
F	HIS186
F	ARG62
F	HIS11
F	GLU89

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
G	HIS186
G	ARG62
G	HIS11
G	GLU89

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
H	HIS186
H	ARG62
H	HIS11
H	GLU89

site_id	CSA9
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
I	HIS186
I	ARG62
I	HIS11
I	GLU89

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)