Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0003908 | molecular_function | methylated-DNA-[protein]-cysteine S-methyltransferase activity |
A | 0006281 | biological_process | DNA repair |
B | 0003824 | molecular_function | catalytic activity |
B | 0003908 | molecular_function | methylated-DNA-[protein]-cysteine S-methyltransferase activity |
B | 0006281 | biological_process | DNA repair |
C | 0003824 | molecular_function | catalytic activity |
C | 0003908 | molecular_function | methylated-DNA-[protein]-cysteine S-methyltransferase activity |
C | 0006281 | biological_process | DNA repair |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 301 |
Chain | Residue |
A | CYS5 |
A | MET7 |
A | CYS24 |
A | HIS29 |
A | HIS85 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 302 |
Chain | Residue |
C | CYS5 |
C | CYS24 |
C | HIS29 |
C | HIS85 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN B 303 |
Chain | Residue |
B | CYS5 |
B | MET7 |
B | CYS24 |
B | HIS29 |
B | HIS85 |
Functional Information from PROSITE/UniProt
site_id | PS00374 |
Number of Residues | 7 |
Details | MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV |
Chain | Residue | Details |
A | ILE143-VAL149 | |
site_id | PS00639 |
Number of Residues | 11 |
Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GLHEIKLLGKG |
Chain | Residue | Details |
A | GLY27-GLY37 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | ACT_SITE: Nucleophile; methyl group acceptor |
Chain | Residue | Details |
A | CYS145 | |
B | CYS145 | |
C | CYS145 | |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: |
Chain | Residue | Details |
A | CYS5 | |
C | CYS24 | |
C | HIS29 | |
C | HIS85 | |
A | CYS24 | |
A | HIS29 | |
A | HIS85 | |
B | CYS5 | |
B | CYS24 | |
B | HIS29 | |
B | HIS85 | |
C | CYS5 | |
Chain | Residue | Details |
A | THR95 | |
B | ASN123 | |
B | ARG128 | |
B | SER151 | |
C | THR95 | |
C | TYR114 | |
C | GLN115 | |
C | ASN123 | |
C | ARG128 | |
C | SER151 | |
A | TYR114 | |
A | GLN115 | |
A | ASN123 | |
A | ARG128 | |
A | SER151 | |
B | THR95 | |
B | TYR114 | |
B | GLN115 | |
Chain | Residue | Details |
A | SER14 | |
B | SER14 | |
C | SER14 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1eh6 |
Chain | Residue | Details |
A | GLU172 | |
A | CYS145 | |
A | ASN137 | |
A | HIS146 | |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1eh6 |
Chain | Residue | Details |
B | GLU172 | |
B | CYS145 | |
B | ASN137 | |
B | HIS146 | |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1eh6 |
Chain | Residue | Details |
C | GLU172 | |
C | CYS145 | |
C | ASN137 | |
C | HIS146 | |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 251 |
Chain | Residue | Details |
A | TYR114 | hydrogen bond donor, proton donor |
A | ASN137 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
A | CYS145 | hydrogen bond donor, nucleophile, proton donor |
A | HIS146 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor |
A | GLU172 | hydrogen bond acceptor, increase basicity |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 251 |
Chain | Residue | Details |
B | TYR114 | hydrogen bond donor, proton donor |
B | ASN137 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
B | CYS145 | hydrogen bond donor, nucleophile, proton donor |
B | HIS146 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor |
B | GLU172 | hydrogen bond acceptor, increase basicity |
site_id | MCSA3 |
Number of Residues | 5 |
Details | M-CSA 251 |
Chain | Residue | Details |
C | TYR114 | hydrogen bond donor, proton donor |
C | ASN137 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
C | CYS145 | hydrogen bond donor, nucleophile, proton donor |
C | HIS146 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor |
C | GLU172 | hydrogen bond acceptor, increase basicity |