Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1YF0

Structural and biochemical analysis of the link between enzymatic activity and oligomerization in AhpC, a bacterial peroxiredoxin.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0045454	biological_process	cell redox homeostasis
A	0051920	molecular_function	peroxiredoxin activity
A	0098869	biological_process	cellular oxidant detoxification
A	0102039	molecular_function	NADH-dependent peroxiredoxin activity
B	0004601	molecular_function	peroxidase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0045454	biological_process	cell redox homeostasis
B	0051920	molecular_function	peroxiredoxin activity
B	0098869	biological_process	cellular oxidant detoxification
B	0102039	molecular_function	NADH-dependent peroxiredoxin activity
C	0004601	molecular_function	peroxidase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0045454	biological_process	cell redox homeostasis
C	0051920	molecular_function	peroxiredoxin activity
C	0098869	biological_process	cellular oxidant detoxification
C	0102039	molecular_function	NADH-dependent peroxiredoxin activity
D	0004601	molecular_function	peroxidase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0045454	biological_process	cell redox homeostasis
D	0051920	molecular_function	peroxiredoxin activity
D	0098869	biological_process	cellular oxidant detoxification
D	0102039	molecular_function	NADH-dependent peroxiredoxin activity
E	0004601	molecular_function	peroxidase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0045454	biological_process	cell redox homeostasis
E	0051920	molecular_function	peroxiredoxin activity
E	0098869	biological_process	cellular oxidant detoxification
E	0102039	molecular_function	NADH-dependent peroxiredoxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 812

Chain	Residue
B	SER85
B	GLU86
B	THR87

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 813

Chain	Residue
C	SER85
C	GLU86
C	THR87

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 814

Chain	Residue
D	SER85
D	GLU86
D	THR87

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 815

Chain	Residue
E	SER85
E	GLU86
E	THR87

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 811

Chain	Residue
A	SER85
A	GLU86
A	THR87

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 802

Chain	Residue
B	TYR38
B	VAL45
B	CYS46
B	PRO47
B	GLU49
B	LEU50
B	ARG119
B	HOH2066

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 801

Chain	Residue
A	TYR38
A	VAL45
A	CYS46
A	PRO47
A	GLU49
A	LEU50
A	ARG119
A	HOH1066

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 803

Chain	Residue
C	TYR38
C	VAL45
C	PRO47
C	GLU49
C	ARG119
C	HOH3064
C	HOH3235

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 804

Chain	Residue
D	TYR38
D	CYS46
D	GLU49
D	LEU50
D	ARG119
D	ARG142

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 805

Chain	Residue
E	TYR38
E	VAL45
E	LEU50
E	ARG119
E	HOH5244

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305\|PubMed:18986167

Chain	Residue	Details
A	PRO47
B	PRO47
C	PRO47
D	PRO47
E	PRO47

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)